FIGURE

Fig. 5

ID

ZDB-FIG-081103-42

Publication

Leung et al., 2008 - The orphan G protein-coupled receptor 161 is required for left-right patterning

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Fig. 5

L–R asymmetry of visceral organs in zebrafish embryos. (A) foxa3 expression marks the gut primordium at 36 hpf showing the liver bud (left) and pancreatic bud (right) in control embryo. (B) Graphical summary of normal visceral asymmetry in control (97.8 ± 1.3%), gpr161 knockdown (32.4 ± 4.1%) and RNA rescued (52.2 ± 3.4%) embryos. t-test (p < 0.01) results were from 6 injection experiments. n was number of total embryos. Error bars were ± SEM. (C) foxa3 expression of liver and pancreatic buds in normal L–R asymmetric position in control, symmetric or heterotaxia in gpr161 knockdown and normal L–R asymmetry in RNA rescued embryos. All scale bars were 100 μm.

Expression Data

Gene:	foxa3
Fish:	WT WT + MO1-gpr161b
Knockdown Reagent:	MO1-gpr161b
Anatomical Terms:	gut liver pancreatic bud
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-gpr161b
Knockdown Reagent:	MO1-gpr161b
Observed In:	determination of left/right symmetry embryonic digestive tract morphogenesis liver pancreatic bud
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 323(1), Leung, T., Humbert, J.E., Stauffer, A.M., Giger, K.E., Chen, H., Tsai, H.J., Wang, C., Mirshahi, T., and Robishaw, J.D., The orphan G protein-coupled receptor 161 is required for left-right patterning, 31-40, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.