FIGURE

Fig. 4

ID

ZDB-FIG-080918-43

Publication

Tobin et al., 2008 - Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome

Other Figures

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Fig. 4

Noncanonical Wnt signaling and NC migration. (A–C) Injection of both dN dvl mRNA and bbs8 MO individually results in inhibition of NCC migration relative to controls. (D) Coinjection of 3 ng of bbs8 MO with dN dvl results in partial rescue of NCC migration by H4-fold relative to bbs8 morphants. (E) Coinjection of dN dvl mRNA with 2 ng of bbs8 MO fails to rescue NCC migration. (F) Injection of 50 pg of myr/pal dvl causes inhibition of NCC migration. (G) Coinjection of myr/pal dvl with 3 ng of bbs8 MO also partially rescues the inhibited NC migration. (H) Graph quantifying the number of streams of crestin-positive NCCs migrating through the trunk. (Scale bar: 200 μm.)

Expression Data

Gene:	crestin
Fish:	WT WT + MO3-ttc8
Knockdown Reagent:	MO3-ttc8
Anatomical Term:	neural crest
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA