FIGURE

Fig. 4

ID

ZDB-FIG-080904-62

Publication

Liu et al., 2008 - Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development

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Fig. 4

Fli1 May Act in Parallel with Cloche but Upstream of Scl and Etsrp

(A?J) WISH on wild-type or Cloche mutant zebrafish embryos injected with combinations of Fli1-VP16 mRNA and/or Scl/Etsrp MOs. 10 s stage, dorsal view, head to top.

(K) A genetic regulatory network linking Bmp to Fli1 at the top of the hemangioblast hierarchy, drawn according to Davidson et al. [29]. Solid lines, direct regulation; dashed lines, no evidence for direct or indirect. Evidence for links quoted in text, apart from Gata2 as a direct Bmp target [32].

Expression Data

Genes:	kdrl tal1
Fish:	AB npas4l^s5/s5 AB + MO2-etsrp AB + MO4-tal1
Knockdown Reagents:	MO2-etsrp MO4-tal1
Anatomical Term:	posterior lateral mesoderm
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npas4l^s5/s5 AB + MO2-etsrp AB + MO4-tal1
Knockdown Reagents:	MO2-etsrp MO4-tal1
Observed In:	embryonic hemopoiesis posterior lateral mesoderm
Stage:	10-13 somites

Phenotype Detail

Acknowledgments

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