FIGURE

Fig. 8

ID

ZDB-FIG-080828-39

Publication

Honjo et al., 2008 - Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons

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Fig. 8

nrg1 and nrg2a act redundantly during DRG neuron formation. (A,B) Elav1 antibody labeling at 4 dpf. Co-injection of nrg1 and nrg2a MOs resulted in absence of DRG neurons (B), whereas DRG neurons are normal in controls (A). (C-H) Whole-mount wild-type (C,E,G) and nrg1 plus nrg2a MO-injected embryos (D,F,H) labeled with crestin riboprobe at 24 hpf (C,D), 27 hpf (E,F) and 30 hpf (G,H). Like erbb3b and erbb2 mutants, double MO-injected embryos have normal early NC migration (C,D) but, at later stages, NC migration is disrupted (E-H). Scale bar: 20 μm.

Expression Data

Gene:	crestin
Antibody:	Ab1-elavl
Fish:	WT WT + MO1-nrg2a + MO2-nrg1
Knockdown Reagents:	MO1-nrg2a MO2-nrg1
Anatomical Terms:	dorsal root ganglion neural crest cell neuron
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-nrg2a + MO2-nrg1
Knockdown Reagents:	MO1-nrg2a MO2-nrg1
Observed In:	dorsal root ganglion neuron neural crest cell neural crest cell migration
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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