FIGURE

Fig. 7

ID

ZDB-FIG-080828-38

Publication

Honjo et al., 2008 - Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons

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Fig. 7

nrg2a alone is unnecessary for DRG neuron formation. DRG neurons labeled with Elavl antibody at 4 dpf. DRG neurons in controls (A,C). DRG neurons are missing from some segments of nrg2a MO-injected embryos (B) but appear normal in nrg2b MO-injected embryos (D). Asterisks indicate absent DRG neurons in B. (E) RT-PCR showing that nrg2a MOs cause incorrect mRNA splicing through 3 dpf, but by 4 dpf, both incorrectly-spliced and correctly-spliced transcripts are present. (F) RT-PCR showing that both the nrg2a and nrg2b MOs cause incorrect splicing at 25 hpf. Scale bar: 20 μm.

Expression Data

Antibody:	Ab1-elavl
Fish:	WT WT + MO1-nrg2a WT + MO1-nrg2b
Knockdown Reagents:	MO1-nrg2a MO1-nrg2b
Anatomical Terms:	dorsal root ganglion neuron
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-nrg2a
Knockdown Reagent:	MO1-nrg2a
Observed In:	dorsal root ganglion neuron peripheral nervous system development
Stage:	Day 4

Phenotype Detail

Acknowledgments

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