FIGURE

Fig. 6

ID

ZDB-FIG-080826-6

Publication

Heanue et al., 2008 - Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species

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Fig. 6

Loss of gene expression following retMO injection verifies that genes are expressed within the ENS. Injection of zebrafish with the retMO, which leads to an absence of enteric neurons in the gut, results in loss of nadl1.1, nadl1.2, dpysl3, and fgf13l expression in the gut of 3dpf embryos B, D, F, H as compared to control morpholino injected zebrafish expression within the gut denoted by arrows in A, C, E, G. fgf13l expression is clearly restricted to a subpopulation of the ENS G. Lateral views are shown. Images for comparison are photographed at the same magnification.

Expression Data

Genes:	dpysl3 fgf13b l1cama l1camb
Fish:	WT WT + MO2-ret
Knockdown Reagent:	MO2-ret
Anatomical Term:	enteric nervous system
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-ret
Knockdown Reagent:	MO2-ret
Observed In:	enteric nervous system enteric nervous system neuron enteric nervous system development posterior intestine neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 125(8), Heanue, T.A., and Pachnis, V., Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species, 687-699, Copyright (2008) with permission from Elsevier. Full text @ Mech. Dev.