ZFIN Morpholino: MO2-ret

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-ret

No data available

Phenotype

Phenotype resulting from MO2-ret

Phenotype	Fish	Figures
enteric nervous system l1camb expression absent, abnormal	WT + MO2-ret	Fig. 6 from Heanue et al., 2008
enteric nervous system fgf13b expression absent, abnormal	WT + MO2-ret	Fig. 6 from Heanue et al., 2008
enteric nervous system dpysl3 expression absent, abnormal	WT + MO2-ret	Fig. 6 from Heanue et al., 2008
enteric nervous system l1cama expression absent, abnormal	WT + MO2-ret	Fig. 6 from Heanue et al., 2008
enteric nervous system neuron absent, abnormal	WT + MO2-ret	Fig. 6 from Heanue et al., 2008

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Phenotype of all Fish created by or utilizing MO2-ret

Phenotype	Fish	Conditions	Figures
gut enteric neuron decreased amount, abnormal	AB + MO2-ret	standard conditions	Fig. S7 from Tilghman et al., 2019
enteric nervous system neuron absent, abnormal	WT + MO2-ret	standard conditions	Fig. 6 from Heanue et al., 2008
enteric neuron ab1-elavl labeling absent, abnormal	WT + MO2-ret	standard conditions	Fig. 2 from Heanue et al., 2008
enteric nervous system l1cama expression absent, abnormal	WT + MO2-ret	standard conditions	Fig. 6 from Heanue et al., 2008
enteric nervous system neuron decreased amount, abnormal	WT + MO2-ret	standard conditions	Fig. 2 from Heanue et al., 2008

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Citations

Include unpublished citations

Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698
Tilghman, J.M., Ling, A.Y., Turner, T.N., Sosa, M.X., Krumm, N., Chatterjee, S., Kapoor, A., Coe, B.P., Nguyen, K.H., Gupta, N., Gabriel, S., Eichler, E.E., Berrios, C., Chakravarti, A. (2019) Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. The New England Journal of Medicine. 380:1421-1432
Bonora, E., Bianco, F., Cordeddu, L., Bamshad, M., Francescatto, L., Dowless, D., Stanghellini, V., Cogliandro, R.F., Lindberg, G., Mungan, Z., Cefle, K., Ozcelik, T., Palanduz, S., Ozturk, S., Gedikbasi, A., Gori, A., Pippucci, T., Graziano, C., Volta, U., Caio, G., Barbara, G., D'Amato, M., Seri, M., Katsanis, N., Romeo, G., De Giorgio, R. (2015) Mutations in RAD21 Disrupt Regulation of APOB in Patients with Chronic Intestinal Pseudo-obstruction. Gastroenterology. 148(4):771-782.e11
Jiang, Q., Arnold, S., Heanue, T., Kilambi, K.P., Doan, B., Kapoor, A., Ling, A.Y., Sosa, M.X., Guy, M., Jiang, Q., Burzynski, G., West, K., Bessling, S., Griseri, P., Amiel, J., Fernandez, R.M., Verheij, J.B., Hofstra, R.M., Borrego, S., Lyonnet, S., Ceccherini, I., Gray, J.J., Pachnis, V., McCallion, A.S., Chakravarti, A. (2015) Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability. American journal of human genetics. 96:581-596
Knight, R.D., Mebus, K., d'Angelo, A., Yokoya, K., Heanue, T., and Roehl, H. (2011) Ret signalling integrates a craniofacial muscle module during development. Development (Cambridge, England). 138(10):2015-2024
Schuster, K., Dambly-Chaudière, C., and Ghysen, A. (2010) Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 107(45):19531-19536
Heanue, T.A., and Pachnis, V. (2008) Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Mechanisms of Development. 125(8):687-699

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