FIGURE

Fig. 4

ID

ZDB-FIG-080604-26

Publication

Laue et al., 2008 - The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

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Fig. 4

Genetic interaction of Brpf1 and Moz and rescue of the brpf1 mutant phenotype by TSA treatment. (A-H) Synergistic enhancement of phenotypes caused by partial loss of Brpf1 and Moz. hoxa2b (A-D; 35 hpf) and bapx1 (E-H; 52 hpf) in situ hybridizations of zebrafish larvae after single or double injections of low amounts of MOs, as indicated in upper right corners. Lateral views. Arrow in D points to absent hoxa2b expression in CNC. Arrow in H indicates ectopic bapx1 expression domain in arch 2. (I-L) Rescued hoxa2b expression in the brpf1 mutant (-/-) after TSA treatment (compare L with K), whereas expression in treated wild-type siblings remains largely unaltered (compare J with I).

Expression Data

Genes:	hoxa2b nkx3-2
Fish:	WT brpf1^{t20002/t20002} WT + MO1-brpf1 WT + MO3-kat6a WT + MO1-brpf1 + MO3-kat6a
Condition:	chemical treatment: trichostatin A
Knockdown Reagents:	MO1-brpf1 MO3-kat6a
Anatomical Terms:	pharyngeal arch 1 pharyngeal arch 2 pharyngeal arch 3-7 rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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