Gene

hoxa2b

ID
ZDB-GENE-990415-98
Name
homeobox A2b
Symbol
hoxa2b Nomenclature History
Previous Names
  • hoxa2
  • etID309949.16 (1)
  • Z-75
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including hindbrain; hindbrain neural keel; hindbrain neural plate; neural crest; and pharyngeal arch. Orthologous to human HOXA2 (homeobox A2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
44 figures from 35 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb428Allele with one delinsUnknownUnknownCRISPR
ihb429Allele with one deletionUnknownUnknownCRISPR
sa36100Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With hoxa2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Microtia with or without hearing impairment (AD) 612290
?Microtia, hearing impairment, and cleft palate (AR) 612290
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Associated With hoxa2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001827 Homeobox protein, antennapedia type, conserved site
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeobox protein, antennapedia type, conserved site Homeodomain Homeodomain, metazoa
UniProtKB:O42365 InterPro 363
UniProtKB:B3DGA4 InterPro 363
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 16
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA hoxa2b-201 (1) Ensembl 1,914 nt
mRNA ottdart00000001850 (1) Havana 1,797 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Et(hoxa2b-SCP1-Ocu.Hbb2:Cre-2A-Cerulean)
  • Danio rerio
  • Oryctolagus cuniclus
1 (2)
Tg(hoxa2b:EGFP)
  • hoxa2b
  • Danio rerio
1 (4)
Tg(hoxa2b-SCP1:Ocu.Hbb2-Cre-2A-Cerulean)
  • hoxa2b
  • Danio rerio
  • Oryctolagus cuniclus
1Tabor et al., 2018
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-45E15ZFIN Curated Data
Contained inPACBUSM1-31B14ZFIN Curated Data
EncodesESTeu715Thisse et al., 2005
EncodescDNAMGC:193940ZFIN Curated Data
EncodescDNAMGC:193947ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanHOXA27
Amino acid sequence comparison (2)
Conserved genome location (synteny) (2)
MouseHoxa26
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
Citations
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