Gene
hoxa2b
- ID
- ZDB-GENE-990415-98
- Name
- homeobox A2b
- Symbol
- hoxa2b Nomenclature History
- Previous Names
-
- hoxa2
- etID309949.16 (1)
- Z-75
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including hindbrain; hindbrain neural keel; hindbrain neural plate; neural crest; and pharyngeal arch. Orthologous to human HOXA2 (homeobox A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu715 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hoxa2b | Zebrafish Nomenclature Committee | |
CRISPR2-hoxa2b | (3) | |
MO1-hoxa2b | N/A | (3) |
MO2-hoxa2b | N/A | Zhang et al., 2015 |
MO3-hoxa2b | N/A | Sundaramoorthi et al., 2023 |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:O42365 | InterPro | 363 | |||||
UniProtKB:B3DGA4 | InterPro | 363 |
1 - 2 of 2
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hoxa2b-201
(1)
|
Ensembl | 1,914 nt | ||
mRNA | ottdart00000001850 (1) | Havana | 1,797 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Et(hoxa2b-SCP1-Ocu.Hbb2:Cre-2A-Cerulean) |
|
| 1 | (2) | |
Tg(hoxa2b:EGFP) |
|
| 1 | (4) | |
Tg(hoxa2b-SCP1:Ocu.Hbb2-Cre-2A-Cerulean) |
|
| 1 | Tabor et al., 2018 |
1 - 3 of 3
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-45E15 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-31B14 | ZFIN Curated Data | |
Encodes | EST | eu715 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:193940 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193947 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131106 (1) | 1797 nt | ||
Genomic | GenBank:CR392024 (1) | 183486 nt | ||
Polypeptide | UniProtKB:B3DGA4 (1) | 363 aa |
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Liu, Z.Z., Guo, J., Lu, Y., Liu, W., Fu, X., Yao, T., Zhou, Y., Xu, H.A. (2019) Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. International journal of experimental pathology. 100(4):234-243
- Parker, H.J., De Kumar, B., Green, S.A., Prummel, K.D., Hess, C., Kaufman, C.K., Mosimann, C., Wiedemann, L.M., Bronner, M.E., Krumlauf, R. (2019) A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nature communications. 10:1189
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
1 - 10 of 88
Show