Gene
nkx3-2
- ID
- ZDB-GENE-030127-1
- Name
- NK3 homeobox 2
- Symbol
- nkx3-2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within bone morphogenesis; embryonic skeletal joint morphogenesis; and embryonic viscerocranium morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including neuromast; notochord; pharyngeal arch; pharyngeal endoderm; and skeletal system. Orthologous to human NKX3-2 (NK3 homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu470 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nkx3-2 | (2) | |
| CRISPR2-nkx3-2 | (2) | |
| CRISPR3-nkx3-2 | (2) | |
| CRISPR4-nkx3-2 | (2) | |
| CRISPR5-nkx3-2 | (2) | |
| CRISPR6-nkx3-2 | (3) | |
| CRISPR7-nkx3-2 | Waldmann et al., 2021 | |
| MO1-nkx3-2 | N/A | (4) |
| MO2-nkx3-2 | N/A | Miller et al., 2003 |
| TALEN1-nkx3-2 | (2) |
1 - 10 of 10
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spondylo-megaepiphyseal-metaphyseal dysplasia | 613330 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|
|
UniProtKB:Q803Z6
|
245 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx3.2-201
(1)
|
Ensembl | 1,964 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-377P23 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-380M10 | ZFIN Curated Data | |
| Encodes | EST | eu470 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:175077 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193888 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193902 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178132 (1) | 1357 nt | ||
| Genomic | GenBank:FP243378 (1) | 44719 nt | ||
| Polypeptide | UniProtKB:Q803Z6 (1) | 245 aa |
- Leyhr, J., Sanchez, S., Dollman, K.N., Tafforeau, P., Haitina, T. (2023) Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants. Frontiers in endocrinology. 14:11089161108916
- Gebuijs, L., Wagener, F.A., Zethof, J., Carels, C.E., Von den Hoff, J.W., Metz, J.R. (2022) Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae. PeerJ. 10:e14338e14338
- Leyhr, J., Waldmann, L., Filipek-Górniok, B., Zhang, H., Allalou, A., Haitina, T. (2022) A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint. eLIFE. 11:
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Castellanos, B.S., Reyes-Nava, N.G., Quintana, A.M. (2021) Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish. BMC Developmental Biology. 21:7
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Waldmann, L., Leyhr, J., Zhang, H., Öhman-Mägi, C., Allalou, A., Haitina, T. (2021) The broad role of Nkx3.2 in the development of the zebrafish axial skeleton. PLoS One. 16:e0255953
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Gebuijs, I.G.E., Metz, J.R., Zethof, J., Carels, C.E.L., Wagener, F.A.D.T.G., Von den Hoff, J.W. (2020) The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae. Mechanisms of Development. 163:103632
- Miyashita, T., Baddam, P., Smeeton, J., Oel, A.P., Natarajan, N., Gordon, B., Palmer, A.R., Crump, J.G., Graf, D., Allison, W.T. (2020) nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish. The Journal of experimental biology. 223(Pt 15):
1 - 10 of 46
Show