ZFIN is now using GRCz12tu for Genomic Data
Gene

nkx3-2

ID
ZDB-GENE-030127-1
Name
NK3 homeobox 2
Symbol
nkx3-2 Nomenclature History
Previous Names
  • nkx3.2 (1)
  • bapx1 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including neuromast; notochord; pharyngeal arch; pharyngeal endoderm; and skeletal system. Orthologous to human NKX3-2 (NK3 homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
45 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx3-2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylo-megaepiphyseal-metaphyseal dysplasia 613330
Associated With nkx3-2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Family IPR050394 Homeobox NK-like transcription regulators
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeobox NK-like transcription regulators Homeodomain Homeodomain, metazoa
UniProtKB:Q803Z6 InterPro 245
UniProtKB:A0AC58H5S6 InterPro 231
UniProtKB:A0AC58H5S7 InterPro 255
UniProtKB:A0AC58H5S9 InterPro 212
UniProtKB:A0AC58H5T2 InterPro 236
UniProtKB:A0AC58H5T4 InterPro 201
UniProtKB:A0AC58H5T7 InterPro 212
UniProtKB:A0AC58H5V0 InterPro 201
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nkx3.2-201 (1)
Ensembl
Ensembl 1,964 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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