FIGURE

Fig. 6

ID

ZDB-FIG-080416-12

Publication

Huang et al., 2008 - Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants

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Fig. 6

Chemical enhancer of reg6 mutation. (A) reg6 is a temperature-sensitive mutation and regenerates almost normally at 20°C. Shown is the regenerating vessels 6 days post amputation at 20°C. Note that they regenerated much more slowly at the low temperature. (B) When treated with 300 μM of the histidine decarboxylase inhibitor, urocanic acid, reg6 siblings developed a significant number of swollen vessels (yellow arrows). Red arrows, amputation plane. (C) The enhancement by urocanic acid of reg6 vessel defects was evaluated at two regenerative stages, during anastomosis (3 dpa at 20°C, n = 10) and plexus formation (6 dpa at 20°C, n = 10) that are both affected by the reg6 mutation [16]. U300, 300 μM of urocanic acid.

Expression Data

Gene:	EGFP
Fish:	reg6^j21/j21; y1Tg
Conditions:	cold shock, physical alteration: anatomical structure chemical treatment: pharmaceutical, physical alteration: anatomical structure
Anatomical Terms:	fin vasculature regenerating fin
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	reg6^j21/j21; y1Tg
Conditions:	cold shock, physical alteration: anatomical structure chemical treatment: pharmaceutical, physical alteration: anatomical structure
Observed In:	fin vasculature
Stage:	Adult

Phenotype Detail

Acknowledgments

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