FIGURE

Fig. 6

ID

ZDB-FIG-080411-9

Publication

Wolman et al., 2008 - Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Other Figures

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Fig. 6

bal embryos have excessively branched axons and MLF growth rates are reduced by TAG-1 or laminin-α1 loss of function.(a) Images from timelapse sequence of MLF axon outgrowth in a bal;Tg(pitx2c:gfp) embryo. Ventral views, anterior to the left, midline is up. The asterisk denotes the caudal-most nucMLF cell. Open and filled arrows and arrowheads label branches from individual axons. The time stamp shows hours: minutes. (b, c) Quantification of the average number of branches per axon (b) and the average growth rate of MLF axons (c). ^#P < 0.001, Kruskal-Wallis ANOVA versus uninjected. *P < 0.05, **P < 0.001, two-tailed t-test versus uninjected. Error bars represent the standard error of the mean. N equals the number of axons. Scale bar = 25 μm.

Expression Data

Gene:	EGFP
Fish:	lama1^uw1/uw1; zy8Tg
Anatomical Terms:	medial longitudinal fasciculus nucleus of the medial longitudinal fasciculus synencephalon
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zy8Tg + MO1-cntn2 lama1^uw1/uw1; zy8Tg
Knockdown Reagent:	MO1-cntn2
Observed In:	axonogenesis medial longitudinal fasciculus axon
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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