ZFIN Morpholino: MO1-cntn2

Target Location

Genome Build: GRCz11Chromosome: 11

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cntn2

No data available

Phenotype

Phenotype resulting from MO1-cntn2

Phenotype	Fish	Figures
axon guidance disrupted, abnormal	zy8Tg + MO1-cntn2	Fig. 3 , Fig. 4 , Fig. 5 from Wolman et al., 2008
axonogenesis neotenous growth, abnormal	zy8Tg + MO1-cntn2	Fig. 3 , Fig. 6 from Wolman et al., 2008
branchiomotor neuron neuron migration decreased occurrence, abnormal	cntn2^zou20/zou20; rw0Tg + MO1-cntn2	Fig. 2 , Fig. 5 from Gurung et al., 2018
facial nerve motor nucleus motor neuron mislocalised, abnormal	rw0Tg + MO1-cntn2	Fig. 2 , Fig. 3 , Fig. 4 , Fig. 5 , Fig. 7 from Sittaramane et al., 2009
medial longitudinal fasciculus morphology, abnormal	zy8Tg + MO1-cntn2	Fig. 3 , Fig. 4 from Wolman et al., 2008

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Phenotype of all Fish created by or utilizing MO1-cntn2

Phenotype	Fish	Conditions	Figures
facial nerve motor nucleus motor neuron mislocalised, abnormal	WT + MO1-cntn2	standard conditions	Fig. 4 from Sittaramane et al., 2009
neuron migration disrupted, abnormal	WT + MO1-cntn2	standard conditions	Fig. 4 from Sittaramane et al., 2009
facial nerve motor nucleus motor neuron mislocalised, abnormal	rw0Tg + MO1-cntn2	standard conditions	Fig. 2 , Fig. 3 , Fig. 5 , Fig. 7 from Sittaramane et al., 2009
rhombomere 4 branchiomotor neuron mislocalised anteriorly, abnormal	rw0Tg + MO1-cntn2	standard conditions	Fig. 2 from Gurung et al., 2018
branchiomotor neuron neuron migration decreased occurrence, abnormal	rw0Tg + MO1-cntn2	standard conditions	Fig. 2 , Fig. 5 from Gurung et al., 2018

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Citations

Include unpublished citations

Gurung, S., Asante, E., Hummel, D., Williams, A., Feldman-Schultz, O., Halloran, M.C., Sittaramane, V., Chandrasekhar, A. (2018) Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Mechanisms of Development. 152:1-12
Stockinger, P., Maître, J.L., and Heisenberg, C.P. (2011) Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube. Development (Cambridge, England). 138(21):4673-4683
Sittaramane, V., Sawant, A., Wolman, M.A., Maves, L., Halloran, M.C., and Chandrasekhar, A. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Developmental Biology. 325(2):363-373
Wolman, M.A., Sittaramane, V., Essner, J.J., Yost, H.J., Chandrasekhar, A., and Halloran, M.C. (2008) Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Neural Development. 3:6
Liu, Y., and Halloran, M.C. (2005) Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(45):10556-10563

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