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ZFIN ID: ZDB-FIG-070219-37
Uechi et al., 2006 - Ribosomal protein gene knockdown causes developmental defects in zebrafish. PLoS One   1(1):e37 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-5

Fig. 3 Schematic Representation of the Extent of Abnormalities in Brain and Body Trunk (A) 6 parts of the brain, 3 parts of the body trunk, and a dorsal view of the trunk are indicated in wild type embryo. a, optic tectum; b, 4th ventricle; c, midbrain-hindbrain boundary; d, anterior part of head; e, rhombencephalon; f, telencephalon; g, body along yolk sac extension; h, tail; i, tip of tail; j, dorsal view of the trunk. (B) The deformations were assessed using a 3-level severity scale; dark gray indicates a severe effect, light gray indicates a mild effect, and white represents no apparent effect. Detailed information and images of the abnormalities in the morphants are available at the zebrafish database (http://zebrafish.med.miyazaki-u.ac.jp).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-rpl11 standard conditions Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin deformed, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otic placode shape, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 trunk bent, abnormal
AB + MO1-rpl24 standard conditions Prim-5 ball increased size, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otic placode shape, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 telencephalon deformed, abnormal
AB + MO1-rpl28 standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fin deformed, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 midbrain hindbrain boundary deformed, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otolith organ decreased size, abnormal
Prim-5 otolith organ deformed, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 telencephalon deformed, abnormal
AB + MO1-rpl35 standard conditions Prim-5 ball increased size, abnormal
Prim-5 ball opaque, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otolith organ deformed, abnormal
Prim-5 post-vent region deformed, abnormal
Prim-5 retina decreased size, abnormal
AB + MO1-rpl35a standard conditions Prim-5 ball increased size, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fin deformed, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 notochord undulate, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otic placode shape, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 telencephalon hypoplastic, abnormal
Prim-5 trunk undulate, abnormal
AB + MO1-rpl36a standard conditions Prim-5 ball increased size, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fin deformed, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain opaque, abnormal
Prim-5 lens increased size, abnormal
Prim-5 nucleate erythrocyte decreased amount, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 otic placode decreased size, abnormal
AB + MO1-rpl38 standard conditions Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin deformed, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 tegmentum opaque, abnormal
Prim-5 telencephalon deformed, abnormal
AB + MO1-rpl5a standard conditions Prim-5 fourth ventricle morphology, abnormal
Prim-5 hindbrain morphology, abnormal
Prim-5 midbrain hindbrain boundary morphology, abnormal
Prim-5 optic tectum morphology, abnormal
Prim-5 post-vent region morphology, abnormal
AB + MO1-rpl5a + MO1-rpl5b standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 fin deformed, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 retina decreased size, abnormal
AB + MO1-rpl5b standard conditions Prim-5 brain morphology, normal
Prim-5 trunk morphology, normal
AB + MO1-rpl6 standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain increased size, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 notochord undulate, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 trunk bent, abnormal
AB + MO1-rplp0 standard conditions Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
AB + MO1-rplp1 standard conditions Prim-5 brain morphology, normal
Prim-5 trunk morphology, normal
AB + MO1-rplp2l standard conditions Prim-5 ball increased size, abnormal
Prim-5 ball opaque, abnormal
Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 notochord bent, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otolith organ decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 tegmentum opaque, abnormal
Prim-5 telencephalon hypoplastic, abnormal
AB + MO1-rps15 standard conditions Prim-5 cerebellum decreased thickness, abnormal
Prim-5 eye color, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region morphology, abnormal
Prim-5 retina decreased size, abnormal
AB + MO1-rps15a standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 tegmentum opaque, abnormal
AB + MO1-rps19 standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum decreased thickness, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain morphology, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 nucleate erythrocyte decreased amount, abnormal
Prim-5 optic tectum aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 otolith organ decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 tegmentum opaque, abnormal
AB + MO1-rps29 standard conditions Prim-5 ball deformed, abnormal
Prim-5 ball increased size, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased length, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain morphology, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 lens increased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 notochord bent, abnormal
Prim-5 nucleate erythrocyte decreased amount, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode aplastic, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
AB + MO1-rps3 standard conditions Prim-5 ball deformed, abnormal
Prim-5 ball opaque, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 extension deformed, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 fin decreased thickness, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle decreased size, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain aplastic, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 telencephalon hypoplastic, abnormal
AB + MO1-rps3a standard conditions Prim-5 ball increased size, abnormal
Prim-5 ball opaque, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 post-vent region curved, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 telencephalon hypoplastic, abnormal
Prim-5 trunk undulate, abnormal
AB + MO1-rps4x standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 hindbrain opaque, abnormal
Prim-5 hindbrain undulate, abnormal
Prim-5 lens decreased size, abnormal
Prim-5 midbrain aplastic, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 telencephalon hypoplastic, abnormal
Prim-5 trunk undulate, abnormal
AB + MO1-rps8a standard conditions Prim-5 ball increased size, abnormal
Prim-5 cerebellum aplastic, abnormal
Prim-5 extension decreased thickness, abnormal
Prim-5 fin aplastic, abnormal
Prim-5 forebrain protruding, abnormal
Prim-5 fourth ventricle increased size, abnormal
Prim-5 fourth ventricle opaque, abnormal
Prim-5 midbrain hindbrain boundary aplastic, abnormal
Prim-5 notochord bent, abnormal
Prim-5 optic tectum increased size, abnormal
Prim-5 optic tectum opaque, abnormal
Prim-5 otic placode decreased size, abnormal
Prim-5 post-vent region bent, abnormal
Prim-5 retina decreased size, abnormal
Prim-5 tegmentum opaque, abnormal
Prim-5 telencephalon morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal PLoS One for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS One