FIGURE

Fig. 6

ID

ZDB-FIG-070129-25

Publication

Jeong et al., 2006 - Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl

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Fig. 6

The requirement of tof/fezl in establishing ngn1-expressing DA progenitor domains. (A–D) ngn1 expression in 20-somite wild-type sibling and the tof mutant embryos shows that ngn1 expression in the basal forebrain (arrows) is reduced at 20 somites (A and B) but appears normal at 28 hpf (C and D). (E and F) ngn1 expression is largely absent in the basal forebrain of tof/fezl morphant. (G and H) TH and tof/fezl in situ (both purple) shows that, although TH⁺ DA neurons are largely absent, the fezl expression appears normal in the ngn1 mutant. di, diencephalon; t, telencephalon. (Scale bars, 32 μm in G and H and 64 μm in A–F.)

Expression Data

Gene:	neurog1
Fish:	WT fezf2^m808/m808 WT + MO2-fezf2 fezf2^m808/+
Knockdown Reagent:	MO2-fezf2
Anatomical Terms:	diencephalon telencephalon
Stage Range:	20-25 somites to Prim-5

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Phenotype Data

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Acknowledgments

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