FIGURE

Fig. 1

ID

ZDB-FIG-061122-9

Publication

Kwak et al., 2006 - Zebrafish pax5 regulates development of the utricular macula and vestibular function

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

cDNA structure and expression of pax5. A: General structure of pax5 splice variants. Brackets indicate exon boundaries. Conserved functional domains, paired (PD), octapeptide (OP), homeo (HD), transactivation (TAD), and inhibitory (ID) are marked. Putative translation start sites (M) are indicated. Binding sites for translation-blocking (TB1 and 2) and splice-blocking (SB1, 2, and 3) morpholinos are shown. Newly identified 5′ (i) and 3′ (ii) sequences are shown in comparison with fugu pax5. Zebrafish and fugu sequences are 100% identical at the amino acid level. B-E: Expression of pax5 in the otic placode at 17 hours postfertilization (hpf; B), in the otic vesicle at 24 hpf (C) and in the utricular macula at 48 hpf (D,E). E: Enlarged view of boxed area in D. Hair cell (hc) supporting cell layers are marked. Arrow, weak expression in the saccule. (A) Dorsal, (B) dorsolateral, and (C,D) lateral views, with anterior to the left. Scale bar = 30 μm in A, 40 μm in B,C, 12.5 μm in D.

Expression Data

Gene:	pax5
Fish:	AB
Anatomical Terms:	hair cell macula utricle otic placode otic vesicle
Stage Range:	14-19 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.