FIGURE

Fig. S5

ID

ZDB-FIG-060823-14

Publication

Walker et al., 2006 - Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning

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Fig. S5

furinA and furinB redundantly activate dlx5a, hand2, and stimulate ventral arch elongation. (A–D) hand2 expression at 55 hpf is dramatically reduced in furinA⁻;furinB MO (D) embryos with respect to WT (A), furinA⁻ (B), and furinB MO (C) embryos. (E–H) dlx5a expression at 36 hpf is strongly reduced in furinA⁻;furinB MO (H) embryos with respect to WT (E), furinA⁻ (F), and furinB MO (G) embryos. (I–L) dlx2a staining at 36 hpf illustrates the arch length. Ventral arch length below the first pouch is substantially reduced in furinA⁻;furinB MO embryos (L) with respect to WT (I), furinA⁻ (J), and furinB MO (K) embryos. a1 and a2 label pharyngeal arch 1 and 2. Dotted lines label pouch 1. m labels the mouth; eye labels the eye. Scale bars: 50 μm.

Expression Data

Genes:	dlx2a dlx5a hand2
Fish:	WT furina^tg419/tg419 WT + MO1-furinb furina^tg419/tg419 + MO1-furinb
Knockdown Reagent:	MO1-furinb
Anatomical Term:	pharyngeal arch
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.