FIGURE

Fig. 2

ID

ZDB-FIG-050729-2

Publication

Albertson et al., 2005 - Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton

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Fig. 2

(A, B) At shield stage, both fgf8 and ntl mRNAs are expressed in wt dorsal forerunner cells DFCs (black arrows). (C) ntl expression is reduced in the margin and DFCs of age-matched ace/fgf8 mutants. (B, C insets) By ∼70% epiboly ntl expression in the midline of ace/fgf8 mutants is indistinguishable from that in age-matched wt embryos (black arrowheads). At this stage, mutant embryos can still be distinguished from wts by reduced ntl expression in DFCs (white arrowheads). (D–F) fgf8 deficiency results in randomization of nodal signaling in the lateral plate mesoderm (LPM) (arrowheads). (D) The nodal-related gene spaw is expressed in the left LPM of wt embryos at 22 somites. Similarly staged ace/fgf8 mutants exhibit reversed (E) and bilaterally (F) expressed spaw in the LPM. (G–I) Normal LR asymmetric development of the diencephalon is disrupted in ace/fgf8 mutants (arrowheads). (G) At 26 hpf, pitx2c is expressed on the left side of the dorsal diencephalon. Expression of this marker is either absent (H) or bilateral (I) in ace/fgf8 mutants.

Expression Data

Genes:	dlx2a nkx2.3
Fish:	WT fgf8a^{ti282a/ti282a}
Anatomical Terms:	mandibular arch skeleton pharyngeal arch 2 skeleton pharyngeal arch 3 skeleton pharyngeal arch 3-7 skeleton pharyngeal arch 4 skeleton pharyngeal arch 5 skeleton pharyngeal arch 6 skeleton pharyngeal arch 7 skeleton pharyngeal pouch 1 pharyngeal pouch 2 pharyngeal pouch 3 pharyngeal pouch 4 pharyngeal pouch 5 pharyngeal pouches 2-6
Stage Range:	Prim-15 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 283(2), Albertson, R.C., and Yelick, P.C., Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton, 310-321, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.