ZFIN ID: ZDB-GENE-991105-4

Gene Name:connexin 43
Gene Symbol: cx43

Previous Names: etID309742.9(1) , shf, zfCx43.3(1) , sof(1) , cx43a1(1) , gja1(1) , short fin
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	33 figure(s) from 10 publications
Directly submitted expression data:	10 figure(s) (27 images) from Rauch et al., 2003 [MGC:55225]
	7 figure(s) (11 images) from Thisse et al., 2004 [MGC:55225]
Wild Type Stages, Structures:	Cleavage:2-cell (0.75h-1.00h) to Adult (90d-730d, breeding adult)
	artery, atrium ... (all 62)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   11 genotypes
Allele(s):   b123, fh300, j7e1, j7e2, j7e3 ... (all 6)

Phenotype: (current status)

Data:	8 figures from 2 publications
Observed in:	cell proliferation, fin, fin regeneration, regenerating fin, surface structure

Knockdown reagents: MO1-cx43 ,   MO2-cx43 (1) ,   MO3-cx43 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	cell communication (more)
Cellular Component	gap junction (more)
Molecular Function	gap junction channel activity (more)

All GO Terms (21)

Protein Families, Domains and Sites:

InterPro:IPR000500 (1) InterPro:IPR002261 (1) InterPro:IPR013092 (1) InterPro:IPR013124 (1) InterPro:IPR017990 (1) InterPro:IPR019570 (1)

PROSITE:PS00407 (1) PROSITE:PS00408 (1)

Pfam:PF00029 (1) Pfam:PF03508 (1) Pfam:PF10582 (1)

Gene Product Description

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ANTIBODIES:

Ab1-cx43 (2)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

cx43 Contained in	[BAC] DKEY-261A18 (1)    (order this)
cx43 Encodes	[cDNA] MGC:55225 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131038 (1)	2873 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR352322 (1)	59134 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:O57474 (1)	381 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:75809 (1)
All Sequence Information (14)

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OTHER  cx43  GENE / MARKER PAGES:

Entrez Gene:30236 (1)

VEGA:OTTDARG00000007101 (1)

Ensembl(Zv8):ENSDARG00000041799 (1)

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MAPPING INFORMATION:

LG:  20  Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	cx43	20
Human	GJA1	6 (q21-q23.2)	OMIM:121014 Entrez Gene:2697
Mouse	Gja1	10 (29.00 cM)	MGI:95713 Entrez Gene:14609
Orthology Details

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CITATIONS   (48)