Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-991105-4
Gene Name: connexin 43
Gene Symbol: cx43
Previous Names: cx43a1 (1), zfCx43.3 (1), etID309742.9 (1), gja1 (1), shf, short fin, sof (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 37 figures from 14 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [MGC:55225]
  10 figures (27 images) from Rauch et al., 2003 [MGC:55225]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  artery, atrium, axial vasculature, brain (all 71) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 16 genotypes
Alleles: b123, cx43_unrecovered, fh300, j7e1, j7e2 (all 6) expand
Knockdown reagents: MO1-cx43, MO2-cx43 (1), MO3-cx43 (1), MO4-cx43 (1), MO5-cx43 (1)
PHENOTYPE
Data: 11 figures from 3 publications
Observed in: cell proliferation, fin, fin regeneration, intermediate cell mass of mesoderm (all 8) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Atrioventricular septal defect 3 600309
Craniometaphyseal dysplasia, autosomal recessive 218400
Hypoplastic left heart syndrome 1 241550
Oculodentodigital dysplasia 164200
Oculodentodigital dysplasia, autosomal recessive 257850
Syndactyly, type III 186100
GENE ONTOLOGY
Ontology GO Term
Biological Process cell communication (more)
Cellular Component gap junction (more)
Molecular Function gap junction channel activity (more)
GO Terms (all 25)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000500 (1)
  • InterPro:IPR002261 (1)
  • InterPro:IPR013092 (1)
  • InterPro:IPR013124 (1)
  • InterPro:IPR017990 (1)
  • InterPro:IPR019570 (1)
  • PROSITE:PS00407 (1)
  • PROSITE:PS00408 (1)
  • Pfam:PF00029 (1)
  • Pfam:PF03508 (1)
  • Pfam:PF10582 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cx43-001 (1) 2917
    cx43-002 (1) 2806
    cx43-003 (1) 913
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-cx43 (1)
    CONSTRUCTS WITH SEQUENCES FROM cx43
    Tg(mitfa:cx43)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cx43 Contained in: [BAC] DKEY-261A18 (1)
    cx43 Encodes: [cDNA] MGC:55225 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131038 (1) 2873 bp
    Genomic GenBank:CR352322 (1) 59134 bp
    Select Tool
    Polypeptide UniProtKB:O57474 (1) 381 aa
    Sequence Clusters UniGene:75809 (1)
    Sequence Information (all 17)
    OTHER cx43 GENE PAGES
  • Gene:30236 (1)
  • VEGA:OTTDARG00000007101 (1)
  • Ensembl(Zv9):ENSDARG00000041799 (1)
  • MAPPING INFORMATION
    Chr: 20 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish cx43 20  
    Human GJA1 6 (6q22.31)
  • OMIM:121014
  • Gene:2697
  • Mouse Gja1 10 ( 28.64 cM)
  • MGI:95713
  • Gene:14609
  • CITATIONS (60)