ZFIN ID: ZDB-GENE-991105-4
Gene Name: connexin 43
Gene Symbol: cx43
Previous Names: cx43a1 (1), etID309742.9 (1), gja1 (1), shf, short fin, sof (1), zfCx43.3 (1)
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 37 figures from 14 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [MGC:55225]
  10 figures (27 images) from Rauch et al., 2003 [MGC:55225]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  artery, atrium, axial vasculature, blood vasculature (all 75) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 Genotypes
Knockdown reagents: MO1-cx43, MO2-cx43 (1), MO3-cx43 (1), MO4-cx43 (1), MO5-cx43 (1)

Allele Type Mutagen Suppliers
b123 Unknown SPONTANEOUS
cx43_unrecovered Point Mutation ENU
  • Moens Lab (order this)
  • fh300 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Moens Lab (order this)
  • j7e1 Point Mutation ENU
    j7e2 Point Mutation ENU
    j7e3 Point Mutation ENU
    PHENOTYPE
    Data: 11 figures from 3 publications
    Observed in: cell proliferation, fin, fin regeneration, intermediate cell mass of mesoderm (all 8) expand
    DISEASE ASSOCIATED WITH cx43 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    atrioventricular septal defect Atrioventricular septal defect 3 600309
    craniometaphyseal dysplasia Craniometaphyseal dysplasia, autosomal recessive 218400
    erythrokeratodermia variabilis Erythrokeratodermia variabilis et progressiva 133200
    hypoplastic left heart syndrome Hypoplastic left heart syndrome 1 241550
    oculodentodigital dysplasia Oculodentodigital dysplasia 164200
    Oculodentodigital dysplasia, autosomal recessive 257850
    syndactyly Syndactyly, type III 186100
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell communication (more)
    Cellular Component gap junction (more)
    Molecular Function gap junction channel activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000500 (1)
  • InterPro:IPR002261 (1)
  • InterPro:IPR013092 (1)
  • InterPro:IPR013124 (1)
  • InterPro:IPR017990 (1)
  • InterPro:IPR019570 (1)
  • PROSITE:PS00407 (1)
  • PROSITE:PS00408 (1)
  • Pfam:PF00029 (1)
  • Pfam:PF03508 (1)
  • Pfam:PF10582 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cx43-001 (1) 2917
    cx43-002 (1) 2806
    cx43-003 (1) 913
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-cx43 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cx43
    Tg(mitfa:cx43)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cx43 Contained in: [BAC] DKEY-261A18 (1) (order this)
    cx43 Encodes: [cDNA] MGC:55225 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131038 (1) 2873 bp
    Genomic GenBank:CR352322 (1) 59134 bp
    Select Tool
    Polypeptide UniProtKB:O57474 (1) 381 aa
    Sequence Clusters UniGene:75809 (1)
    Sequence Information (all 17)
    OTHER cx43 GENE PAGES
  • Gene:30236 (1)
  • VEGA:OTTDARG00000007101 (1)
  • Ensembl(Zv9):ENSDARG00000041799 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cx43 20  
    Human GJA1 6 (6q22.31)
  • OMIM:121014
  • Gene:2697
  • Mouse Gja1 10 ( 28.64 cM)
  • MGI:95713
  • Gene:14609
  • Orthology Details
    CITATIONS (65)