ZFIN ID: ZDB-GENE-991105-4
Gene Name: connexin 43
Gene Symbol: cx43

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cx43a1 (1), etID309742.9 (1), gja1 (1), shf, short fin, sof (1), stopsel (1), stp, zfCx43.3 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 42 figures from 18 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [MGC:55225]
  10 figures (27 images) from Rauch et al., 2003 [MGC:55225]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  artery, atrium, axial vasculature, blood vasculature (all 75) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b123 Unknown Unknown Unknown SPONTANEOUS
cx43_unrecovered Point Mutation Unknown Unknown ENU
fh300 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • j7e1 Point Mutation Unknown Missense ENU
    j7e2 Point Mutation Unknown Missense ENU
    j7e3 Point Mutation Unknown Missense ENU
    ou2028 Indel Unknown Unknown TALEN
    sa29432 Point Mutation Unknown Premature Stop ENU
    sa32313 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37126 Point Mutation Unknown Premature Stop ENU
    tl28d Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-cx43, MO2-cx43 (1), MO3-cx43 (1), MO4-cx43 (1), MO5-cx43 (1) (all 6) expand
    PHENOTYPE
    Data: 19 figures from 5 publications
    Observed in: bone growth, bone morphogenesis, caudal fin, caudal vertebra (all 25) expand
    DISEASE ASSOCIATED WITH cx43 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    atrioventricular septal defect Atrioventricular septal defect 3 600309
    craniometaphyseal dysplasia Craniometaphyseal dysplasia, autosomal recessive 218400
    erythrokeratodermia variabilis Erythrokeratodermia variabilis et progressiva 133200
    hypoplastic left heart syndrome Hypoplastic left heart syndrome 1 241550
    oculodentodigital dysplasia Oculodentodigital dysplasia 164200
    Oculodentodigital dysplasia, autosomal recessive 257850
    syndactyly Syndactyly, type III 186100
    Palmoplantar keratoderma with congenital alopecia 104100
    Palmoplantar keratoderma with congenital alopecia 104100
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell communication (more)
    Cellular Component gap junction (more)
    Molecular Function gap junction channel activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000500 (1)
  • InterPro:IPR002261 (1)
  • InterPro:IPR013092 (1)
  • InterPro:IPR013124 (1)
  • InterPro:IPR017990 (1)
  • InterPro:IPR019570 (1)
  • PROSITE:PS00407 (1)
  • PROSITE:PS00408 (1)
  • Pfam:PF00029 (1)
  • Pfam:PF03508 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cx43-001 (1) 2917
    cx43-002 (1) 2806
    cx43-003 (1) 913
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-cx43 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cx43
    Tg(cx43:cx43), Tg(cx43:mCherry), Tg(mitfa:cx43)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cx43Contained in: [BAC] DKEY-261A18 (1) (order this)
    cx43Encodes: [cDNA] MGC:55225 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131038 (1) 2873bp
    Genomic GenBank:CR352322 (1) 59134bp
    Select Tool
    Polypeptide UniProtKB:O57474 (1) 381aa
    Sequence Clusters UniGene:75809 (1)
    Sequence Information (all 17)
    OTHER cx43 GENE PAGES
  • Gene:30236 (1)
  • VEGA:OTTDARG00000007101 (1)
  • Ensembl(GRCz10):ENSDARG00000041799 (1)
  • ORTHOLOGY for cx43 (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human GJA1 6
  • Gene:2697
  • OMIM:121014
  • HGNC:4274
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (4)
    Mouse Gja1 10
  • MGI:95713
  • Gene:14609
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (78)