Research
General Information
ZIRC
ZFIN: Gene: sox3
ZFIN ID: ZDB-GENE-980526-333

Gene Name:SRY-box containing gene 3
Gene Symbol: sox3
Previous Names: sb:cb493(1) , wu:fd02a08(1) , zgc:110279(1) , id:ibd2036(1)
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 54 figure(s) from 22 publications
Directly submitted expression data: 6 figure(s) (32 images) from Thisse et al., 2001 [cb493]
  12 figure(s) (43 images) from Rauch et al., 2003 [fc66h05]
  4 figure(s) (4 images) from Kudoh et al., 2001 [ibd2036]
Wild Type Stages, Structures: Cleavage:2-cell (0.75h-1.00h) to Larval:Day 5 (120.00h-144.00h, 3.9mm, 6 teeth)
  alar plate midbrain region, basal plate midbrain region ... (all 47)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   3 genotypes
Allele(s):   fh276, fh277, unrec_sox3
Phenotype: (current status)
  Data: 5 figures from Dee et al., 2008
  Observed in: brain, central canal, central nervous system, central nervous system development, eye ... (all 12)
Knockdown reagents: MO1-sox3 (1) ,   MO2-sox3 (1) ,   MO3-sox3 (1) ,   MO4-sox3 (1)

GENE PRODUCTS:

Gene Ontology
Ontology Qualifier GO Term
Biological Process positive regulation of transcription factor activity (more)
Cellular Component nucleus
Molecular Function sequence-specific DNA binding transcription factor activity (more)
All GO Terms (9)

Protein Families, Domains and Sites:
  • InterPro:IPR000910 (1)
  • InterPro:IPR009071 (1)
  • InterPro:IPR022097 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF12336 (1)
  • Gene Product Description


    ANTIBODIES:
    Ab1-Sox3 (1)


    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    sox3 Contained in [BAC] CH211-143L19 (1)    (order this) , CH211-285J6 (1)    (order this)
    sox3 Encodes [EST] cb493 (1)    (order this) , fc66h05 (1)    (order this) , fd02a08 (1) , ibd2036 (1)    (order this)
    [cDNA] MGC:110279 (1)    (order this) , MGC:174245 (1)    (order this)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001811 (1) 1781 bp
    Genomic GenBank:BX088596 (1) 142350 bp
    Polypeptide UniProtKB:A9JSZ3 (1) 300 aa
    Sequence Clusters UniGene:104569 (1)
    All Sequence Information (25)

    OTHER  sox3  GENE / MARKER PAGES:

  • Entrez Gene:30529 (1)
  • Ensembl(Zv8):ENSDARG00000053569 (1)

  • MAPPING INFORMATION:
      LG:  14 ,  9    Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish sox3  14 ,  9
    Human SOX3  X (q27.1)
  • OMIM:313430
  • Entrez Gene:6658
  • Mouse Sox3  X (24.50 cM)
  • MGI:98365
  • Entrez Gene:20675
  • Orthology Details

    CITATIONS   (52)