ZFIN ID: ZDB-GENE-980526-333

Gene Name:SRY-box containing gene 3
Gene Symbol: sox3

Previous Names: sb:cb493(1) , wu:fd02a08(1) , zgc:110279(1) , id:ibd2036(1)
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	54 figure(s) from 22 publications
Directly submitted expression data:	6 figure(s) (32 images) from Thisse et al., 2001 [cb493]
	12 figure(s) (43 images) from Rauch et al., 2003 [fc66h05]
	4 figure(s) (4 images) from Kudoh et al., 2001 [ibd2036]
Wild Type Stages, Structures:	Cleavage:2-cell (0.75h-1.00h) to Larval:Day 5 (120.00h-144.00h, 3.9mm, 6 teeth)
	alar plate midbrain region, basal plate midbrain region ... (all 47)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   3 genotypes
Allele(s):   fh276, fh277, unrec_sox3

Phenotype: (current status)

Data:	5 figures from Dee et al., 2008
Observed in:	brain, central canal, central nervous system, central nervous system development, eye ... (all 12)

Knockdown reagents: MO1-sox3 (1) ,   MO2-sox3 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	Qualifier	GO Term
Molecular Function	Contributes to	transcription factor activity (more)
Biological Process		positive regulation of transcription factor activity (more)
Cellular Component		nucleus

All GO Terms (9)

Protein Families, Domains and Sites:

InterPro:IPR000910 (1) InterPro:IPR009071 (1)

PROSITE:PS50118 (1)

Pfam:PF00505 (1)

Gene Product Description

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ANTIBODIES:

Ab1-Sox3 (1)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

sox3 Contained in	[BAC] CH211-143L19 (1)    (order this) , CH211-285J6 (1)    (order this)
sox3 Encodes	[EST] cb493 (1)    (order this) , fc66h05 (1)    (order this) , fd02a08 (1) , ibd2036 (1)    (order this) [cDNA] MGC:110279 (1)    (order this) , MGC:174245 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001001811 (1)	1781 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX088596 (1)	142350 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:A9JSZ3 (1)	300 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:104569 (1)
All Sequence Information (26)

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OTHER  sox3  GENE / MARKER PAGES:

Entrez Gene:30529 (1)

Ensembl(Zv8):ENSDARG00000053569 (1)

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MAPPING INFORMATION:

LG:  14 ,  9    Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	sox3	14 ,  9
Human	SOX3	X (q27.1)	OMIM:313430 Entrez Gene:6658
Mouse	Sox3	X (24.50 cM)	MGI:98365 Entrez Gene:20675
Orthology Details

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CITATIONS   (41)