Gene

smad9

ID

ZDB-GENE-031014-1

Name

SMAD family member 9

Symbol

smad9 Nomenclature History

Previous Names

madh9
smad8
zgc:103407 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in dorsal/ventral pattern formation; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to localize to several cellular components, including integral component of membrane; nucleus; and transcription factor complex. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Orthologous to human SMAD9 (SMAD family member 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103407 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary pulmonary hypertension	Alliance	Pulmonary hypertension, primary, 2	615342

Associated With smad9 Via Experimental Models

Human Disease	Fish	Conditions	Citations
arteriovenous malformations of the brain	zf531Tg + MO1-smad9	standard conditions	Walcott et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001132	SMAD domain, Dwarfin-type
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Family	IPR013790	Dwarfin
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily

Domain Details Per Protein

Protein	Length	Dwarfin	MAD homology 1, Dwarfin-type	MAD homology, MH1	SMAD domain, Dwarfin-type	SMAD/FHA domain superfamily	SMAD-like domain superfamily	SMAD MH1 domain superfamily
UniProtKB:F1QXZ9 InterPro	466

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smad9-001 (1) Ensembl	Ensembl	2,359 nt	Select Tool
mRNA	smad9-201 (1) Ensembl	Ensembl	5,365 nt	Select Tool ZFIN BLAST
mRNA	smad9-205 (1) Ensembl	Ensembl	2,691 nt	Select Tool ZFIN BLAST
mRNA	smad9-206 (1) Ensembl	Ensembl	2,291 nt	Select Tool ZFIN BLAST
ncRNA	smad9-002 (1) Ensembl	Ensembl	917 nt	Select Tool
ncRNA	smad9-003 (1) Ensembl	Ensembl	526 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-smad	polyclonal	smad1 smad5 smad9	IgG	Rabbit	IHC WB	Cell Signaling Technology, Inc.	79

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations