ZFIN is now using GRCz12tu for Genomic Data
Gene
krt8
- ID
- ZDB-GENE-030411-5
- Name
- keratin 8
- Symbol
- krt8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be a structural constituent of skin epidermis. Acts upstream of or within camera-type eye development and neural crest cell migration. Predicted to be located in cytoplasm and nuclear matrix. Predicted to be active in keratin filament. Is expressed in several structures, including EVL; cardiovascular system; integument; pectoral fin; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Meesmann corneal dystrophy 2; ectodermal dysplasia 4; hair disease (multiple); liver disease (multiple); and skin disease (multiple). Orthologous to several human genes including KRT8 (keratin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb186 (10 images)
- MGC:85764 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Keratin, type II | Keratin type II head |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NWF6 | InterPro | 520 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers