Gene
bmp15
- ID
- ZDB-GENE-030131-6115
- Name
- bone morphogenetic protein 15
- Symbol
- bmp15 Nomenclature History
- Previous Names
-
- fi35a05
- wu:fi35a05
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity. Involved in female sex differentiation; negative regulation of oocyte development; and oocyte maturation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and premature ovarian failure. Is expressed in several structures, including brain; digestive system; gonad; heart; and steroid hormone secreting cell. Orthologous to human BMP15 (bone morphogenetic protein 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 2 | Alliance | Ovarian dysgenesis 2 | 300510 |
| ovarian dysgenesis 2 | Alliance | Premature ovarian failure 4 | 300510 |
| primary ovarian insufficiency 4 | Alliance | Ovarian dysgenesis 2 | 300510 |
| primary ovarian insufficiency 4 | Alliance | Premature ovarian failure 4 | 300510 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|
|
UniProtKB:Q58FS4
|
384 |
Interactions and Pathways
No data available
Plasmids
No data available