ZFIN ID: ZDB-GENE-030131-6115
Gene Name: bone morphogenetic protein 15
Gene Symbol: bmp15    Nomenclature History

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Previous Names: fi35a05, wu:fi35a05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have cytokine activity. Involved in female sex differentiation; negative regulation of oocyte development; and oocyte maturation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and premature ovarian failure. Is expressed in several structures, including brain; digestive system; gonad; heart; and steroid hormone secreting cell. Orthologous to human BMP15 (bone morphogenetic protein 15).
Genome Resources: Alliance (1),  Gene:334183 (1),  Ensembl(GRCz11):ENSDARG00000037491 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
uc31 Small Deletion Unknown Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bmp15 N/A 3
TALEN1-bmp15 1
DISEASE ASSOCIATED WITH bmp15 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 2 Alliance Ovarian dysgenesis 2 300510
Premature ovarian failure 4 300510
DISEASE ASSOCIATED WITH bmp15 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oocyte maturation (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA bmp15-201 (1)    Ensembl 2001
bmp15-202 (1)    Ensembl 640
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-bmp15 polyclonal Rabbit IHC, WB 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM bmp15 No data available
MARKER RELATIONSHIPS
bmp15 Contained in: [BAC] CH73-71A10 (1), CH211-122F10 (1)
bmp15 Encodes: [EST] fi35a05
[cDNA] MGC:152740 (1), MGC:191878 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001020484 (1) 1611 nt
Genomic GenBank:BX957362 (1) 191638 nt
Select Tool
Polypeptide UniProtKB:Q0VG66 (1) 394 aa
Sequence Information (all 23)
ORTHOLOGY for bmp15 ( Chr: 7 )
CITATIONS (43)