ZFIN is now using GRCz12tu for Genomic Data
Gene
hbs1l
- ID
- ZDB-GENE-030131-2987
- Name
- HBS1-like translational GTPase
- Symbol
- hbs1l Nomenclature History
- Previous Names
-
- wu:fc23c07
- zgc:55400
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process. Part of cytoplasmic exosome (RNase complex). Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55400 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Cabrera-Quio et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR015033 | HBS1-like protein, N-terminal |
| Domain | IPR054696 | GTP-eEF1A, C-terminal domain |
| Family | IPR050100 | Translation factor GTPase superfamily members |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR037189 | HBS1-like protein, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GTP-eEF1A, C-terminal domain | HBS1-like protein, N-terminal | HBS1-like protein, N-terminal domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Translational (tr)-type GTP-binding domain | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal | Translation elongation factor EFTu-like, domain 2 | Translation factor GTPase superfamily members | Translation protein, beta-barrel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YV72 | InterPro | 576 | |||||||||
| UniProtKB:F1Q5Z6 | InterPro | 682 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers