ZFIN is now using GRCz12tu for Genomic Data
Gene
fanci
- ID
- ZDB-GENE-030131-2905
- Name
- FA complementation group I
- Symbol
- fanci Nomenclature History
- Previous Names
-
- fc21c10
- wu:fc21c10
- zgc:152941
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in DNA damage response and positive regulation of protein ubiquitination. Predicted to be part of DNA repair complex. Predicted to be active in nucleoplasm. Is expressed in head; heart; nervous system; pectoral fin; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group I | Alliance | Fanconi anemia, complementation group I | 609053 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR029305 | FANCI solenoid 1 cap |
| Domain | IPR029308 | FANCI solenoid 1 domain |
| Domain | IPR029310 | FANCI helical domain 1 |
| Domain | IPR029312 | FANCI helical domain 2 |
| Domain | IPR029313 | FANCI solenoid 3 domain |
| Domain | IPR029314 | FANCI solenoid 4 domain |
| Domain | IPR029315 | FANCI solenoid 2 domain |
| Family | IPR026171 | Fanconi anemia group I protein |
Domain Details Per Protein
| Protein | Additional Resources | Length | FANCI helical domain 1 | FANCI helical domain 2 | FANCI solenoid 1 cap | FANCI solenoid 1 domain | FANCI solenoid 2 domain | FANCI solenoid 3 domain | FANCI solenoid 4 domain | Fanconi anemia group I protein |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PUU2 | InterPro | 1376 | ||||||||
| UniProtKB:F1R3B9 | InterPro | 1327 | ||||||||
| UniProtKB:A0AC58IUC8 | InterPro | 1327 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers