Research
General Information
ZIRC
ZFIN: Gene: gbx2
ZFIN ID: ZDB-GENE-020509-2

Gene Name:gastrulation brain homeo box 2
Gene Symbol: gbx2
Previous Names: fd07f12, wu:fd07f12(1) , gbx-2(1)
Nomenclature History

GENE EXPRESSION:(current status)
All expression data: 22 figure(s) from 12 publications
Directly submitted expression data: 10 figure(s) (39 images) from Rhinn et al., 2003 [mb2]
Wild Type Stages, Structures: Zygote:1-cell (0.00h-0.75h) to Hatching:Long-pec (48.00h-60.00h)
  caudal fin, cerebellum ... (all 20)
Curated microarray expression: GEO  (1)
MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   3 genotypes
Allele(s):   fh248, fh253, unrec_gbx2
Phenotype: (current status)
GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Molecular Function DNA binding (more)
Biological Process regulation of cellular transcription (more)
Cellular Component nucleus
All GO Terms (7)

Protein Families, Domains and Sites:
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR012287 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)

    • Gene Product Description

    CONSTRUCTS WITH SEQUENCE FROM gbx2:
    Tg(gbx2.1-hsp70l:EGFP), Tg(gbx2.4-hsp70l:EGFP), Tg(gbx2.2-hsp70l:EGFP), Tg(gbx2.3-hsp70l:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    gbx2 Encodes [EST] fd07f12 (1) , mb2 (1)
    [cDNA] MGC:73023 (1)    (order this)
    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152964 (1) 2113 bp
    Genomic GenBank:AF288762 (1) 4240 bp
    Polypeptide UniProtKB:Q8AXK9 (1) 342 aa
    Sequence Clusters UniGene:17548 (1)
    All Sequence Information (16)
    OTHER  gbx2  GENE / MARKER PAGES:

  • Entrez Gene:245948 (1)
  • Ensembl(Zv8):ENSDARG00000002933 (1)
    • MAPPING INFORMATION:
      LG:  6    Details   View Map: Merged  Individual Panels
    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish gbx2  6
    Human GBX2  2 (q37)
  • OMIM:601135
  • Entrez Gene:2637
    • Mouse Gbx2  1 (65.00 cM)
  • MGI:95668
  • Entrez Gene:14472
    • Orthology Details
    CITATIONS   (30)