ZFIN ID: ZDB-PUB-020402-5
The expression of gbx-2 during zebrafish embryogenesis
Su, Y. and Meng, A.
Date: 2002
Source: Mechanisms of Development   113(1): 107-110 (Journal)
Registered Authors: Meng, Anming
Keywords: zebrafish; gbx-2; isthmic regions; otic vesicle; telencephalon; diencephalon; pronephric duct; branchial arch
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Brain/embryology*
  • Chick Embryo
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins/biosynthesis*
  • Humans
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • RNA, Antisense/biosynthesis
  • RNA, Messenger/metabolism
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Xenopus Proteins
  • Zebrafish
  • Zebrafish Proteins
PubMed: 11900984 Full text @ Mech. Dev.
Gbx-2 is a homeobox gene essential for normal development of the midbrain and the anterior hindbrain. Zebrafish gbx-2 shares an overall similarity of 67.8, 68.1, 60.6 and 66.5% in amino acid sequence to human, mouse, chick and Xenopus Gbx-2, respectively. The expression of zebrafish gbx-2 is initially, before the completion of epiboly, restricted to the prospective posterior midbrain. The expression remains detectable until the end of pharyngula period. The gbx-2 mRNA is also detected in the otic vesicles, the dorsoposterior telencephalon, the rostral branchial arches, the pronephric duct and median fin fold.