ZFIN ID: ZDB-GENE-001212-1

Gene Name:ATPase, Na+/K+ transporting, alpha 1 polypeptide
Gene Symbol: atp1a1

Previous Names: atp[a]1B1(1) , had(1) , snk(1) , wu:fa03c03, cb70(1) , wu:fb92h10(1) , heart and mind(1) , snakehead(1) , atp1a1a.1
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	25 figure(s) from 11 publications
Directly submitted expression data:	6 figure(s) (19 images) from Rauch et al., 2003 [fb81h09]
	6 figure(s) (22 images) from Thisse et al., 2001 [cb70]
Wild Type Stages, Structures:	Cleavage:2-cell (0.75h-1.00h) to Adult (90d-730d, breeding adult)
	adaxial cell, alar plate midbrain region ... (all 34)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   19 genotypes
Allele(s):   hi3475Tg, la1, m115, m273, m291 ... (all 14)

Phenotype: (current status)

Data:	21 figures from 7 publications
Observed in:	anatomical system, apical part of cell, blood circulation, brain, central canal ... (all 26)

Knockdown reagents: MO1-atp1a1 (1) ,   MO2-atp1a1 (1) ,   MO3-atp1a1 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	otolith development (more)
Cellular Component	integral to membrane (more)
Molecular Function	sodium:potassium-exchanging ATPase activity (more)

All GO Terms (31)

Protein Families, Domains and Sites:

InterPro:IPR001757 (1) InterPro:IPR004014 (1) InterPro:IPR005775 (1) InterPro:IPR005834 (1) InterPro:IPR006068 (1) InterPro:IPR006069 (1) InterPro:IPR008250 (1) InterPro:IPR013200 (1) InterPro:IPR018303 (1)

PROSITE:PS00154 (1)

Pfam:PF00122 (1) Pfam:PF00689 (1) Pfam:PF00690 (1) Pfam:PF00702 (1) Pfam:PF08282 (1)

Gene Product Description

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

atp1a1 Contained in	[BAC] DKEY-208K14 (1)    (order this)
atp1a1 Encodes	[EST] cb70 (1)    (order this) , fa03c03 (1) , fb81h09 (1)    (order this) , fb92h10 (1) [cDNA] MGC:55250 (1)    (order this) , MGC:77580 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131686 (2)	3497 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU185242 (1)	180192 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZU25 (1)	1028 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:75307 (1)
All Sequence Information (22)

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OTHER  atp1a1  GENE / MARKER PAGES:

Entrez Gene:64612 (1)

VEGA:OTTDARG00000029782 (1)

Ensembl(Zv8):ENSDARG00000002791 (1)

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MAPPING INFORMATION:

LG:  1    Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	atp1a1	1
Human	ATP1A1	1 (p21)	OMIM:182310 Entrez Gene:476
Mouse	Atp1a1	3 (48.40 cM)	MGI:88105 Entrez Gene:11928
Orthology Details

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CITATIONS   (44)