Gene
eef1a2
- ID
- ZDB-GENE-040718-64
- Name
- eukaryotic translation elongation factor 1 alpha 2
- Symbol
- eef1a2 Nomenclature History
- Previous Names
-
- zgc:92085
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; early infantile epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 38 | Alliance | Intellectual developmental disorder, autosomal dominant 38 | 616393 |
| developmental and epileptic encephalopathy 33 | Alliance | Developmental and epileptic encephalopathy 33 | 616409 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | eef1a2s3012/s3012 | standard conditions | Griffin et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Family | IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
| Family | IPR050100 | Translation factor GTPase superfamily members |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Translational (tr)-type GTP-binding domain | Translation elongation factor EF1A, eukaryotic/archaeal | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal | Translation elongation factor EFTu-like, domain 2 | Translation factor GTPase superfamily members | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DHT2
|
463 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eef1a2-201
(1)
|
Ensembl | 2,030 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-eef1a2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 | |
| Ab2-eef1a2 | polyclonal | Rabbit |
|
Abcam plc
|
2 |
Plasmids
No data available