ZFIN ID: ZDB-GENE-040718-64
Gene Name: eukaryotic translation elongation factor 1 alpha 2
Gene Symbol: eef1a2    Nomenclature History

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Previous Name: zgc:92085

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; early infantile epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).
Genome Resources: Alliance (1),  Gene:436644 (1),  Ensembl(GRCz11):ENSDARG00000006838 (1)
GENE EXPRESSION
All Expression Data: Fig. 3 from Cao et al., 2017
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3224 Point Mutation Unknown Premature Stop ENU
sa12662 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13094 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37650 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39401 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-eef1a2 N/A 1
    MO2-eef1a2 N/A 1
    DISEASE ASSOCIATED WITH eef1a2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 38 Alliance Mental retardation, autosomal dominant 38 616393
    early infantile epileptic encephalopathy 33 Alliance Epileptic encephalopathy, early infantile, 33 616409
    DISEASE ASSOCIATED WITH eef1a2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translation (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR031157 Tr-type G domain, conserved site
    Domain IPR000795 Transcription factor, GTP-binding domain
    Domain IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    Domain IPR004161 Translation elongation factor EFTu-like, domain 2
    Family IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
    Homologous_superfamily IPR009000 Translation protein, beta-barrel domain superfamily
    Homologous_superfamily IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eef1a2-201 (1)    Ensembl 2030
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-eef1a2 polyclonal IgG Rabbit WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eef1a2 No data available
    MARKER RELATIONSHIPS
    eef1a2 Contained in: [BAC] DKEY-103A3 (1) (order this)
    eef1a2 Encodes: [cDNA] MGC:92085 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002371 (1) 2051 nt
    Genomic RefSeq:NW_018395138 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8RKC7 (1) 463 aa
    Sequence Information (all 12)
    ORTHOLOGY for eef1a2 ( Chr: 23 )
    CITATIONS (18)