Gene

tjp1a

ID

ZDB-GENE-031001-2

Name

tight junction protein 1a

Symbol

tjp1a Nomenclature History

Previous Names

tjp1.1 (1)
tjp1
zo-1 (1)
cb817 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within pigmentation and slit diaphragm assembly. Located in bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

49 figures from 28 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb817 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tjp1a Human Ortholog

No data available

Associated With tjp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000906	ZU5 domain
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR035597	ZO-1, SH3 domain
Family	IPR005417	Tight junction protein ZO
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Tight junction protein ZO	ZO-1, SH3 domain	ZU5 domain
UniProtKB:A0A8M9QHT2 InterPro	1721
UniProtKB:A0A8M2BG85 InterPro	1722
UniProtKB:A0A8M3B198 InterPro	1721
UniProtKB:A0A8M3B1A2 InterPro	1692
UniProtKB:A0A8M3B464 InterPro	1725
UniProtKB:A0A8M3AUB4 InterPro	1714
UniProtKB:A0A8M3AUA1 InterPro	1733
UniProtKB:A0A8M2BG91 InterPro	1712
UniProtKB:A0A8M9Q2H7 InterPro	1621
UniProtKB:A0A8M3BB27 InterPro	1663
UniProtKB:A0A8M3AUA6 InterPro	1659
UniProtKB:A0A8M3BB23 InterPro	1734
UniProtKB:A0A8M9PPT8 InterPro	1641
UniProtKB:A0A8M3B467 InterPro	1647

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tjp1a-201 (1) Ensembl	Ensembl	4,902 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-202 (1) Ensembl	Ensembl	6,999 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-203 (1) Ensembl	Ensembl	676 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-204 (1) Ensembl	Ensembl	612 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-205 (1) Ensembl	Ensembl	485 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-206 (1) Ensembl	Ensembl	1,035 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-207 (1) Ensembl	Ensembl	544 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-209 (1) Ensembl	Ensembl	206 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-210 (1) Ensembl	Ensembl	784 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-211 (1) Ensembl	Ensembl	5,101 nt	Select Tool ZFIN BLAST
mRNA	tjp1a-212 (1) Ensembl	Ensembl	5,074 nt	Select Tool ZFIN BLAST
ncRNA	tjp1a-004 (1) Ensembl	Ensembl	751 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tjp1	monoclonal	tjp1a tjp1b	IgG1 , k	Mouse	IHC	Life Technologies (Invitrogen) Thermo Fisher Scientific (Lab Vision)	236
Ab2-tjp1	polyclonal	tjp1a		Rabbit	IHC	Life Technologies (Invitrogen)	24
Ab5-tjp1a	polyclonal	tjp1a		Rabbit	IHC		2
Ab4-tjp1a	polyclonal	tjp1a		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations