ZFIN ID: ZDB-GENE-070925-1
Gene Name: tight junction protein 1b
Gene Symbol: tjp1b    Nomenclature History

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Previous Names: tjp1.2 (1), si:dkey-33l14.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Involved in gap junction assembly and synapse assembly. Predicted to localize to the bicellular tight junction. Is expressed in several structures, including axial mesoderm; cardiovascular system; epidermis; nervous system; and pleuroperitoneal region. Orthologous to human TJP1 (tight junction protein 1).
Genome Resources: Alliance (1),  Gene:565459 (1),  Ensembl(GRCz11):ENSDARG00000079374 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1370 Indel Unknown Unknown CRISPR
fh448 Small Deletion Unknown Unknown CRISPR
fh449 Indel Unknown Unknown CRISPR
fh451 Indel Unknown Unknown CRISPR
sa13104 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15532 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44339 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tjp1b 3
    CRISPR2-tjp1b
    3
    MO1-tjp1b N/A 1
    DISEASE ASSOCIATED WITH tjp1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tjp1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gap junction assembly (more)
    Cellular Component bicellular tight junction (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000906 ZU5 domain
    Domain IPR001315 CARD domain
    Domain IPR001452 SH3 domain
    Domain IPR001478 PDZ domain
    Family IPR005417 Tight junction protein ZO
    Family IPR005418 Tight junction protein ZO-1
    Domain IPR008144 Guanylate kinase-like domain
    Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    Homologous_superfamily IPR011029 Death-like domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Domain IPR035597 ZO-1, SH3 domain
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Homologous_superfamily IPR036034 PDZ superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tjp1b-201 (1)    Ensembl 7408
    tjp1b-202 (1)    Ensembl 7626
    tjp1b-203 (1)    Ensembl 7618
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tjp1 monoclonal IgG1 , k Mouse IHC Life Technologies (Invitrogen)
    Thermo Fisher Scientific (Lab Vision)
    167
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tjp1b No data available
    MARKER RELATIONSHIPS
    tjp1b Contained in: [BAC] CH73-339E3 (1), DKEY-33L14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009298130 (1)
    Genomic GenBank:CR847962 (1) 209896 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A1D5NS76 (1) 2005 aa
    Sequence Information (all 48)
    ORTHOLOGY for tjp1b ( Chr: 25 )
    CITATIONS (27)