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ZIRC
ZFIN ID: ZDB-GENE-031001-2
Gene Name: tight junction protein 1a
Gene Symbol: tjp1a    Nomenclature History

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Previous Names: tjp1.1 (1), tjp1, zo-1 (1), cb817 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in pigmentation. Localizes to the bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).
Genome Resources: Alliance (1),  Gene:378845 (1),  Ensembl(GRCz11):ENSDARG00000077506 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh463 Small Deletion Unknown Unknown CRISPR
sa7069 Point Mutation Unknown Premature Stop ENU
sa13285 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20982 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34097 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40924 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tnh009b Point Mutation Unknown Premature Stop ENU
    twc2 Point Mutation Unknown Premature Stop ENU
    twl1 Point Mutation Unknown Premature Stop ENU
    twl4 Point Mutation Unknown Premature Stop ENU
    twlc19 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tjp1a
    2
    CRISPR2-tjp1a
    2
    CRISPR3-tjp1a 1
    DISEASE ASSOCIATED WITH tjp1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tjp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pigmentation (more)
    Cellular Component bicellular tight junction (more)
    Molecular Function protein binding (more)
    GO Terms (all 3)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tjp1a-202 (1)    Ensembl 6999
    tjp1a-203 (1)    Ensembl 676
    tjp1a-204 (1)    Ensembl 612
    tjp1a-205 (1)    Ensembl 485
    tjp1a-206 (1)    Ensembl 1035
    tjp1a-207 (1)    Ensembl 544
    tjp1a-209 (1)    Ensembl 206
    tjp1a-210 (1)    Ensembl 784
    ncRNA tjp1a-004 (1)    Ensembl 751
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tjp1 monoclonal IgG1 , k Mouse IHC Life Technologies (Invitrogen)
    Thermo Fisher Scientific (Lab Vision)
    166
    Ab2-tjp1 polyclonal Rabbit IHC Life Technologies (Invitrogen)
    21
    Ab5-tjp1a polyclonal Rabbit IHC 2
    Ab4-tjp1a polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tjp1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:tjp1a-mCherry) hsp70l mCherrytjp1a Danio rerio 1 1
    MARKER RELATIONSHIPS
    tjp1a Contained in: [BAC] DKEY-1H4 (1) (order this)
    tjp1a Encodes: [EST] cb817 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005168933 (1) 7284 bp
    Genomic GenBank:BX649429 (1) 268480 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QMK9 (1) 1689 aa
    Sequence Clusters UniGene:160253 (1)
    Sequence Information (all 53)
    ORTHOLOGY for tjp1a ( Chr: 7 )
    CITATIONS (54)