Gene

tjp1a

ID
ZDB-GENE-031001-2
Name
tight junction protein 1a
Symbol
tjp1a Nomenclature History
Previous Names
  • tjp1.1 (1)
  • tjp1
  • zo-1 (1)
  • cb817 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have cell adhesion molecule binding activity. Involved in pigmentation and slit diaphragm assembly. Localizes to bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).
Genome Resources
Note
None
Expression
All Expression Data
43 figures from 22 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tjp1a Human Ortholog
No data available
Associated With tjp1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000906 ZU5 domain
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR035597 ZO-1, SH3 domain
Family IPR005417 Tight junction protein ZO
Family IPR005418 Tight junction protein ZO-1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily Tight junction protein ZO Tight junction protein ZO-1 ZO-1, SH3 domain ZU5 domain
UniProtKB:E9QET4 1624
UniProtKB:X1WGR1 26
UniProtKB:A0A1D5NT08 69
UniProtKB:A0A2L2BH75 1624
UniProtKB:A0A1D5NSI3 16
UniProtKB:A0A2R8Q396 1680
UniProtKB:A0A2R8QMK9 1689
UniProtKB:A0A1D5NSJ0 141
UniProtKB:A0A1D5NSN9 345
UniProtKB:X1WG30 103
UniProtKB:E7F2W2 1633
UniProtKB:A0A1D5NS61 147
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tjp1 monoclonal IgG1 , k Mouse
  • IHC
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision)
181
Ab2-tjp1 polyclonal Rabbit
  • IHC
Life Technologies (Invitrogen)
24
Ab5-tjp1a polyclonal Rabbit
  • IHC
2
Ab4-tjp1a polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations