Gene

ctps1a

ID

ZDB-GENE-030131-808

Name

CTP synthase 1a

Symbol

ctps1a Nomenclature History

Previous Names

ctps
ctpsa
cb1040 (1)
wu:fb49e03 (1)
wu:fe17b03 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have CTP synthase activity and identical protein binding activity. Involved in notochord development. Predicted to localize to cytoophidium and cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and pectoral fin bud. Orthologous to human CTPS1 (CTP synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb1040 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Dzaki et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctps1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 24	Alliance	Immunodeficiency 24	615897

Associated With ctps1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017456	CTP synthase, N-terminal
Domain	IPR017926	Glutamine amidotransferase
Domain	IPR033828	CTP synthase GATase domain
Family	IPR004468	CTP synthase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029062	Class I glutamine amidotransferase-like