ZFIN ID: ZDB-LAB-980209-8
Streisinger Lab
Contact Person:
Email: walker@uoneuro.uoregon.edu
Address: Institute of Neuroscience 1254 University of Oregon Eugene, OR 97403-1254 USA
Country: United States
Phone: c/o Charline Walker (541) 346-4506
Line Designation: b

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George Streisinger
Born December 27, 1927 in Budapest, Hungary
Died August 11, 1984 while at the Oregon Coast near Florence

George Streisinger is considered by many of his peers to be the founding father of zebrafish research. At the end of his life, his evolving research focused on how genetic mutations affect nervous system development in lower vertebrates and in 1981, he published a method using zebrafish that allowed screening for mutants among parthenogenetic offspring of mutagenized females.

He came to the University of Oregon by a circuitous route. In 1960, Dr. Streisinger had accepted a teaching position at Brandeis University while finishing up 4 years of work at Cold Spring Harbor and the Carnegie Institution of Washington. At a meeting at Cold Spring Harbor that summer, he met Dr. Frank Stahl, a member of the University of Oregon's Institute of Molecular Biology, who talked him into going to Oregon instead. Dr. Streisinger formed a strong bond with the University and with his beloved state of Oregon.

During the course of his scientific career, Dr. Streisinger was given several prestigious awards. He was a Guggenheim Fellow in 1972; in 1975, after being at the University of Oregon for 15 years, he was selected as a member of the National Academy of Sciences, making him only the second Oregonian to receive the distinction. He was also chosen to receive the Howard Taylor Ricketts Award from the University of Chicago in 1982.

Using T4 phage as a model system, Dr. Streisinger's research made major contributions in deciphering the genetic code, understanding the nature of frameshift mutations and the structure of the T4 phage genome.

George Streisinger dreamed of using the power of the same molecular principles to study the genetics and development of a vertebrate. He chose the zebrafish as a model system. The fish was small enough to keep the large numbers required for genetic studies, but large enough to do classical embryological manipulations such as transplantations. It was a daring change of course, and he was keenly aware of the critical views of his colleagues. It took almost ten years before he was ready to publish his first zebrafish paper. Much of this time was spent describing the normal morphological and functional development of the zebrafish embryo and developing genetic and husbandry techniques.

Following Dr. Streisinger's death, his lab members strove to keep his research progressing. In a letter written one week later, one of his postdocs, David Jonah Grunwald, describes the loss to the lab. "Our lab and the Institute were very devoted to George. He extended an enormous amount of enthusiasm and support for our work and for our personal lives. George had very broad interests that spanned beyond the borders of his expertise. Virtually all members of the Institute (of Molecular Biology) discussed, sporadically or often, their scientific results with him. His range of interests, his willingness to reflect on the activities of others, and his generous spirit combined to make him a central force in guiding and maintaining the communal atmosphere of the Institute..." Fortunately, Dr. Charles Kimmel, a professor in the Institute of Neuroscience, who had been encouraged by Dr. Streisinger to work with zebrafish, stepped in to "adopt" the lab and continue the work in developmental genetics.

George Streisinger's research is still being carried on by his colleagues at the University of Oregon. These include the labs of Drs. Charles Kimmel, Monte Westerfield, Judith Eisen, John Postlethwait, and James Weston. His proven use of the zebrafish in research has spread to over 100 developmental and genetics labs in 28 countries. Many of the mutants produced in the Streisinger Lab are still alive and well and may be obtained by contacting Bill Trevarrow, the Director of University of Oregon Zebrafish Facility, FAX (541) 346-4548, e-mail: trevarro@uoneuro.uoregon.edu.

Streisinger, George

Grunwald, D.J. and Streisinger, G. (1992) Induction of recessive lethal and specific locus mutations in the zebrafish with ethyl nitrosourea. Genetics research. 59:103-116
Grunwald, D.J., and Streisinger, G. (1992) Induction of recessive lethal mutations in zebrafish with ultraviolet light. Genetics research. 59:93-101
Felsenfeld, A.L., Walker, C., Westerfield, M., Kimmel, C., and Streisinger, G. (1990) Mutations affecting skeletal muscle myofibril structure in the zebrafish. Development (Cambridge, England). 108:443-459
Streisinger, G., Coale, F., Taggart, C., Walker, C., and Grunwald, D.J. (1989) Clonal origin of cells in the pigmented retina of the zebrafish eye. Developmental Biology. 131(1):60-69
Grunwald, D.J., Kimmel, C.B., Westerfield, M., Walker, C., and Streisinger, G. (1988) A neural degeneration mutation that spares primary neurons in the zebrafish. Developmental Biology. 126:115-128
Streisinger, G., Singer, F., Walker, C., Knauber, D., and Dower, N. (1986) Segregation analysis and gene-centromere distances in zebrafish. Genetics. 112:311-319
Grunwald, D.J., Streisinger, G., and Walker, C. (1985) Clonal origins of cells in the zebrafish eye. Journal of cellular biochemistry. (Suppl.) 9B:270
Kimmel, C.B., Grunwald, D.J., Walker, C., Westerfield, M., and Streisinger, G. (1985) Neuronal degeneration mutations that spare primary neurons in the zebrafish. Soc. Neurosci. Abstr.. 11:647
Nawrocki, L., BreMiller, R., Streisinger, G., and Kaplan, M. (1985) Larval and adult visual pigments of the zebrafish, Brachydanio rerio. Vision Research. 25:1569-1576
Streisinger, G. (1984) Attainment of minimal biological variability and measurements of genotoxicity: production of homozygous diploid zebra fish. National Cancer Institute monograph. 65:53-58
Chakrabarti, S., Streisinger, G., Singer, F., and Walker, C. (1983) Frequency of gamma-ray induced specific locus and recessive lethal mutations in mature germ cells of the zebrafish, Brachydanio rerio. Genetics. 103:109-124
Walker, C. and Streisinger, G. (1983) Induction of mutations by gamma-rays in pregonial germ cells of zebrafish embryos. Genetics. 103:125-136
Golin, J., Grunwald, D.J., Singer, F., Walker, C., and Streisinger, G. (1982) Ethyl nitroso urea induced germline mutations in zebrafish Brachydanio-rerio. Genetics. 100:S27
Streisinger, G., Walker, C., Dower, N., Knauber, D., and Singer, F. (1981) Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature. 291(5813):293-296
Branchek, T.A. and Streisinger, G. (1980) Photoreceptor development in the zebrafish. Soc. Neurosci. Abstr.. 6:194