ZFIN ID: ZDB-LAB-110907-1
Liu Lab
PI/Director: Liu, Feng
Contact Person: Liu, Feng
Email: liuf@ioz.ac.cn
URL: http://www.biomembrane.ioz.ac.cn/Enliuf.asp
Address: State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences 1 Beichen West Road, Chaoyang District Beijing, 100101 China
Country: China
Phone: 86-10-64807307
Fax: 86-10-64807313
Line Designation: ioz

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We are interested in Hematopoiesis and Cardiovascular development biology, with particular focus on Hemangioblast formation, Artery/Vein specification and Hematopoietic Stem Cell (HSC) development, using the zebrafish as a model organism. Our previous work has demonstrated that several ETS transcription factors involved in blood and endothelial development. Our current work focuses on key signal transduction pathways and gene regulatory network (GRN) controlling hematopoietic/cardiovascular stem cell differentiation to better understand molecular mechanisms of programming/reprogramming of these cells for potential therapeutic application.

Li, Xiajuan Graduate Student Liu, Zhibin Graduate Student Lu, Xinyan Graduate Student
Wang, Lu Graduate Student Wang, Shifeng Graduate Student Wei, Yonglong Graduate Student
Yang, Xiaodan Graduate Student Zhang, Chunxia Graduate Student Zhang, Panpan Graduate Student
Gao, Ya Research Staff Ma, Dongyuan Research Staff

Lv, P., Ma, D., Gao, S., Zhang, Y., Bae, Y.K., Liang, G., Gao, S., Choi, J.H., Kim, C.H., Wang, L., Liu, F. (2020) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 15(3):749-760
Shi, B., Zhang, J., Heng, J., Gong, J., Zhang, T., Li, P., Sun, B.F., Yang, Y., Zhang, N., Zhao, Y.L., Wang, H.L., Liu, F., Zhang, Q.C., Yang, Y.G. (2020) RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome biology. 21:120
Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696
Lu, X., Zhang, Y., Liu, F., Wang, L. (2020) Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. Journal of immunology (Baltimore, Md. : 1950). 204(9):2447-2454
Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11
Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839
Tu, H.Q., Qin, X.H., Liu, Z.B., Song, Z.Q., Hu, H.B., Zhang, Y.C., Chang, Y., Wu, M., Huang, Y., Bai, Y.F., Wang, G., Han, Q.Y., Li, A.L., Zhou, T., Liu, F., Zhang, X.M., Li, H.Y. (2018) Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nature communications. 9:5277
Choi, J.P., Wang, R., Yang, X., Wang, X., Wang, L., Ting, K.K., Foley, M., Cogger, V., Yang, Z., Liu, F., Han, Z., Liu, R., Baell, J., Zheng, X. (2018) Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations. Science advances. 4:eaau0731
Wang, N., Zhang, B., Jin, F., Gao, D., Liu, F., Liu, H., Jiang, Y. (2018) Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway. Journal of pharmaceutical and biomedical analysis. 160:314-322
Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports. 18:1922-1934
Wang, L., Liu, Z., Lin, H., Ma, D., Tao, Q., Liu, F. (2017) Epigenetic regulation of left-right asymmetry by DNA methylation. The EMBO journal. 36(20):2987-2997
Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., Jia, Q., Wang, X., Qin, G., Yao, J., Wang, X., Zheng, Q., Zhang, R., Li, Y., Luo, A., Zhang, N., Shi, G., Wang, Y., Ying, H., Liu, Z., Wang, H., Meng, A., Zhou, Q., Wei, H., Liu, F., Zhao, J. (2017) Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 130(20):2161-2170
Zhang, C., Chen, Y., Sun, B., Wang, L., Yang, Y., Ma, D., Lv, J., Heng, J., Ding, Y., Xue, Y., Lu, X., Xiao, W., Yang, Y.G., Liu, F. (2017) m6A modulates haematopoietic stem and progenitor cell specification.. Nature. 549(7671):273-276
Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4
Yan, H., Zhang, C., Wang, Z., Tu, T., Duan, H., Luo, Y., Feng, J., Liu, F., Yan, X. (2017) CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Scientific Reports. 7:7442
Ma, D., Xue, Y., Zhang, Y., Sun, Y., Meng, A., Liu, F. (2016) The rising zebrafish research in China: Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society. Journal of genetics and genomics = Yi chuan xue bao. 43(10):617-620
Zhou, W., He, Q., Zhang, C., He, X., Cui, Z., Liu, F., Li, W. (2016) BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. eLIFE. 5
Wei, Y., Xu, J., Zhang, W., Wen, Z., Liu, F. (2016) RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). 143(12):2103-10
Wang, X.Q., Tang, Z.X., Yu, D., Cui, S.J., Jiang, Y.H., Zhang, Q., Wang, J., Yang, P.Y., Liu, F. (2016) Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 7(8):8823-38
Hu, M., Bai, Y., Zhang, C., Liu, F., Cui, Z., Chen, J., Peng, J. (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genetics. 12:e1005881
Ma, D., Liu, F. (2015) Genome Editing and Its Applications in Model Organisms. Genomics, proteomics & bioinformatics. 13(6):336-44
Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
Wang, S., He, Q., Ma, D., Xue, Y., Liu, F. (2015) Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Developmental Cell. 34(6):621-31
Lu, X., Wei, Y., Liu, F. (2015) Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell discovery. 1:15027
Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
Wang, H., Li, Y., Wang, S., Zhang, Q., Zheng, J., Yang, Y., Qi, H., Qu, H., Zhang, Z., Liu, F., Fang, X. (2015) Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. Biochemical and Biophysical Research Communications. 460(4):923-30
Tu, T., Zhang, C., Yan, H., Luo, Y., Kong, R., Wen, P., Ye, Z., Chen, J., Feng, J., Liu, F., Wu, J.Y., Yan, X. (2015) CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Research. 25(3):275-87
Peng, J., Xu, W., Teoh, C.L., Han, S., Kim, B., Samanta, A., Er, J.C., Wang, L., Yuan, L., Liu, X., Chang, Y.T. (2015) High-efficiency In Vitro and In Vivo Detection of Zn2+ by Dye-assembled Upconversion Nanoparticles. Journal of the American Chemical Society. 137(6):2336-42
Zhou, Y., Ge, R., Wang, R., Liu, F., Huang, Y., Liu, H., Hao, Y., Zhou, Q., Wang, C. (2015) UXT potentiates angiogenesis by attenuating Notch signaling. Development (Cambridge, England). 142(4):774-86
He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106
Qiao, J., Cui, S.J., Xu, L.L., Chen, S.J., Yao, J., Jiang, Y.H., Peng, G., Fang, C.Y., Yang, P.Y., Liu, F. (2015) Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 6(2):1171-89
Yang, X., Gao, Y., Huang, Z., Chen, X., Ke, Z., Zhao, P., Yan, Y., Liu, R., Qu, J. (2015) Fluorescent probe based on heteroatom containing styrylcyanine: pH-sensitive properties and bioimaging in vivo. Materials science & engineering. C, Materials for biological applications. 52:97-102
Wei, Y., Ma, D., Gao, Y., Zhang, C., Wang, L., Liu, F. (2014) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 124(10):1578-85
Ping, X.L., Sun, B.F., Wang, L., Xiao, W., Yang, X., Wang, W.J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.S., Zhao, X., Li, A., Yang, Y., Dahal, U., Lou, X.M., Liu, X., Huang, J., Yuan, W.P., Zhu, X.F., Cheng, T., Zhao, Y.L., Wang, X., Rendtlew Danielsen, J.M., Liu, F., and Yang, Y.G. (2014) Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Research. 24(2):177-189
Lu, X., Li, X., He, Q., Gao, J., Gao, Y., Liu, B., and Liu, F. (2013) miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Research. 23(12):1356-68
Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L., and Zhao, Y. (2013) Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology. 203(4):575-583
Wang, L., Bammler, T.K., Beyer, R.P., and Gallagher, E.P. (2013) Copper-Induced Deregulation of microRNA Expression in the Zebrafish Olfactory System. Environmental science & technology. 47(13):7466-7474
Wang, L., Shang, N., Feng, H., Guo, Q., and Dai, H. (2013) Molecular cloning of grass carp (Ctenopharyngodon idellus) T-bet and GATA-3, and their expression profiles with IFN-γ in response to grass carp reovirus (GCRV) infection. Fish physiology and biochemistry. 39(4):793-805
Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75
Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W., and Liu, J. (2013) Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 153(4):773-784
Zhang, C.X., and Liu, F. (2013) A brief protocol for high-resolution whole mount in situ hybridization in zebrafish. Yi chuan = Hereditas. 35(4):522-528
Zhang, C., Patient, R., and Liu, F. (2013) Hematopoietic stem cell development and regulatory signaling in zebrafish. Biochimica et biophysica acta. General subjects. 1830(2):2370-2374
Wang, L., and Gallagher, E.P. (2013) Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicology and applied pharmacology. 266(2):177-186
Ma, D., Wei, Y., and Liu, F. (2013) Regulatory mechanisms of thymus and T cell development. Developmental and comparative immunology. 39(1-2):91-102
Ye, Z., Zhang, C., Tu, T., Sun, M., Liu, D., Lu, D., Feng, J., Yang, D., Liu, F., and Yan, X. (2013) Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nature communications. 4:2803
Ma, D., Wang, L., Wang, S., Gao, Y., Wei, Y., and Liu, F. (2012) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(51):21040-21045
Liu, Z., and Liu, F. (2012) Cautious use of fli1a:EGFP transgenic zebrafish in vascular research. Biochemical and Biophysical Research Communications. 427(1):223-226
Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10
Zhang, P., and Liu, F. (2011) In vivo imaging of hematopoietic stem cell development in the zebrafish. Frontiers of Medicine. 5(3):239-47
Miller, L.C., Freter, S., Liu, F., Taylor, J.S., Patient, R., and Begbie, J. (2010) Separating early sensory neuron and blood vessel patterning. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3297-3302
Mo, S., Wang, L., Li, Q., Li, J., Li, Y., Thannickal, V.J., and Cui. Z. (2010) Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish. Developmental Biology. 344(1):210-223
Yao, J., Zhou, J., Liu, Q., Lu, D., Wang, L., Qiao, X., and Jia, W. (2010) Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish. PLoS One. 5(6):e10945
Wang, L., Zhou, J.Y., Yao, J.H., Lu, D.R., Qiao, X.J., and Jia, W. (2010) U6 promoter-driven siRNA injection has nonspecific effects in zebrafish. Biochemical and Biophysical Research Communications. 391(3):1363-1368
Ciau-Uitz, A., Liu, F., and Patient, R. (2010) Genetic control of hematopoietic development in Xenopus and zebrafish. The International journal of developmental biology. 54(6-7):1139-1143
Liu, F., and Patient, R. (2008) Genome-Wide Analysis of the Zebrafish ETS Family Identifies Three Genes Required for Hemangioblast Differentiation or Angiogenesis. Circulation research. 103(10):1147-1154
Kawamura, H., Li, X., Goishi, K., van Meeteren, L.A., Jakobsson, L., Cebe-Suarez, S., Shimizu, A., Edholm, D., Ballmer-Hofer, K., Kjellen, L., Klagsbrun, M., and Claesson-Welsh, L. (2008) Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood. 112(9):3638-3649
Liu, F., Walmsley, M., Rodaway, A., and Patient, R. (2008) Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development. Current biology : CB. 18(16):1234-1240
Zhang, S.H., Yao, J.H., Song, H.D., Wang, L., and Xue, J.L. (2008) Cloning and expression of translation elongation factor 2 (EF-2) in zebrafish. DNA sequence : the journal of DNA sequencing and mapping. 19(1):1-7
Wang, L., Yao, J., Cheng, L., Chen, L., Ruan, Z., Xue, J. (2007) The morphological influence of human TCP10L microinjected in zebrafish. The Journal of Fudan University (Natural Science). 46(3):371-376
Wang, L., Yao, J., Chen, L., Chen, J., Xue, J., and Jia, W. (2007) Expression and possible functional roles of cytochromes P450 2J1 (zfCyp 2J1) in zebrafish. Biochemical and Biophysical Research Communications. 352(4):850-855
Yao, J., Wang, L., Chen, L., Zhang, S., Zhao, Q., Jia, W., and Xue, J. (2006) Cloning and developmental expression of the DEC1 ortholog gene in zebrafish. Gene expression patterns : GEP. 6(8):919-927
Zhang, S.H., Yao, J.H., Song, H.D., Wang, L., and Xue, J.L. (2006) Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish. The International journal of developmental biology. 50(4):399-403
Chen, L., Yao, J.H., Zhang, S.H., Wang, L., Song, H.D., and Xue, J.L. (2005) Slit-like 2, a novel zebrafish slit homologue that might involve in zebrafish central neural and vascular morphogenesis. Biochemical and Biophysical Research Communications. 336(1):364-371
Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
Liu, F. and Wen, Z. (2002) Cloning and expression pattern of the lysozyme C gene in zebrafish. Mechanisms of Development. 113(1):69-72