PUBLICATION

Regulatory mechanisms of thymus and T cell development

Authors
Ma, D., Wei, Y., and Liu, F.
ID
ZDB-PUB-120111-28
Date
2013
Source
Developmental and comparative immunology   39(1-2): 91-102 (Review)
Registered Authors
Liu, Feng, Ma, Dongyuan, Wei, Yonglong
Keywords
thymopoiesis, T cell, signaling, transcription factors, mouse, zebrafish
MeSH Terms
  • Animals
  • Cell Differentiation/genetics
  • Cell Differentiation/immunology
  • Clonal Selection, Antigen-Mediated/genetics
  • Epithelial Cells/immunology*
  • Humans
  • Mice
  • T-Lymphocytes/immunology*
  • Thymus Gland/immunology*
  • Zebrafish/immunology
PubMed
22227346 Full text @ Dev. Comp. Immunol.
Abstract
The thymus is a central hematopoietic organ which produces mature T lymphocytes with diverse antigen specificity. During development, the thymus primordium is derived from the third pharyngeal endodermal pouch, and then differentiates into cortical and medullary thymic epithelial cells (TECs). TECs represent the primary functional cell type that forms the unique thymic epithelial microenvironment which is essential for intrathymic T-cell development, including positive selection, negative selection and emigration out of the thymus. Our understanding of thymopoiesis has been greatly advanced by using several important animal models. This review will describe progress on the molecular mechanisms involved in thymus and T cell development with particular focus on the signaling and transcription factors involved in this process in mouse and zebrafish.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes