ZFIN ID: ZDB-LAB-090225-1
Holtzman Lab
PI/Director: Holtzman, Nathalia Glickman
Contact Person:
Email: nathalia.holtzman@qc.cuny.edu
URL: http://qcpages.qc.edu/Biology/Holtzman/Holtzman.html
Address: Queens College SB D328 65-30 Kissena Blv Flushing, New York NY, 11367
Country: United States
Phone: 718-997-3678
Fax: 718-997-3445
Line Designation: None assigned


The lab is interested in organogenesis with a focus on heart development. We have three areas of research:

Interactions between the endocardium and myocardium during heart tube formation.

Cardiac maturation throughout fish life.

Epicardial formation and maturation.

Morgan, Keisha Graduate Student Parise, Daniel Graduate Student Birne, Marie Fish Facility Staff
Lam, Stella Technical Staff Fatakhova, Karina Gorbacz, David
Gutierrez, Deanna Munarova, Aida Ziv, Dorit

Prabhudesai, S., Bensabeur, F.Z., Abdullah, R., Basak, I., Baez, S., Alves, G., Holtzman, N.G., Larsen, J.P., Møller, S.G. (2016) LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Journal of neuroscience research. 94(8):717-35
Holtzman, N.G., Iovine, M.K., Liang, J.O., Morris, J. (2016) Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio. Genetics. 203:1069-1089
Arif Pavel, M., Lv, C., Ng, C., Yang, L., Kashyap, P., Lam, C., Valentino, V., Fung, H.Y., Campbell, T., Møller, S.G., Zenisek, D., Holtzman, N.G., Yu, Y. (2016) Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant. Proceedings of the National Academy of Sciences of the United States of America. 113(17):E2363-72
Singleman, C., Holtzman, N.G. (2014) Growth and Maturation in the Zebrafish, Danio Rerio: A Staging Tool for Teaching and Research. Zebrafish. 11(4):396-406
Lenhart, K.F., Holtzman, N.G., Williams, J.R., and Burdine, R.D. (2013) Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry. PLoS Genetics. 9(1):e1003109
Singleman, C., and Holtzman, N.G. (2012) Analysis of post-embryonic heart development and maturation in the zebrafish, Danio rerio. Developmental dynamics : an official publication of the American Association of Anatomists. 241(12):1993-2004
Singleman, C., and Holtzman, N.G. (2011) Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio. Journal of visualized experiments : JoVE.
Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D., and Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current biology : CB. 18(23):1882-1888
de Campos-Baptista, M.I., Holtzman, N.G., Yelon, D., and Schier, A.F. (2008) Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3624-3633
Baker, K., Holtzman, N.G., and Burdine, R.D. (2008) Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 105(37):13924-13929
Holtzman, N.G., Schoenebeck, J.J., Tsai, H.J., and Yelon, D. (2007) Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development (Cambridge, England). 134(13):2379-2386
Glickman, N.S., Kimmel, C.B., Jones, M.A., and Adams, R.J. (2003) Shaping the zebrafish notochord. Development (Cambridge, England). 130(5):873-887
Glickman, N.S. and Yelon, D. (2002) Cardiac development in zebrafish: coordination of form and function. Seminars in cell & developmental biology. 13(6):507-513
Glickman, N.S. and Yelon, D. (2002) Analysis of the cellular behaviors driving cardiac fusion in zebrafish. Developmental Biology. 247(2):473