|ZFIN ID: ZDB-PUB-030116-8|
Cardiac development in zebrafish: coordination of form and function
Glickman, N.S. and Yelon, D.
|Source:||Seminars in cell & developmental biology 13(6): 507-513 (Journal)|
|Registered Authors:||Holtzman, Nathalia Glickman, Yelon, Deborah|
|PubMed:||12468254 Full text @ Sem. Cell Dev. Biol.|
Glickman, N.S. and Yelon, D. (2002) Cardiac development in zebrafish: coordination of form and function. Seminars in cell & developmental biology. 13(6):507-513.
ABSTRACTOrganogenesis is a dynamic process involving multiple phases of pattern formation and morphogenesis. For example, heart formation involves the specification and differentiation of cardiac precursors, the integration of precursors into a tube, and the remodeling of the embryonic tube to create a fully functional organ. Recently, the zebrafish has emerged as a powerful model organism for the analysis of cardiac development. In particular, zebrafish mutations have revealed specific genetic requirements for cardiac fate determination, migration, fusion, tube assembly, looping, and remodeling. These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis.
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