PUBLICATION
Cardiac development in zebrafish: coordination of form and function
- Authors
- Glickman, N.S. and Yelon, D.
- ID
- ZDB-PUB-030116-8
- Date
- 2002
- Source
- Seminars in cell & developmental biology 13(6): 507-513 (Journal)
- Registered Authors
- Holtzman, Nathalia Glickman, Yelon, Deborah
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Movement
- Embryonic and Fetal Development*
- Heart/embryology
- Heart/growth & development*
- Morphogenesis
- Myocytes, Cardiac/cytology
- Zebrafish/embryology*
- PubMed
- 12468254 Full text @ Sem. Cell Dev. Biol.
Citation
Glickman, N.S. and Yelon, D. (2002) Cardiac development in zebrafish: coordination of form and function. Seminars in cell & developmental biology. 13(6):507-513.
Abstract
Organogenesis is a dynamic process involving multiple phases of pattern formation and morphogenesis. For example, heart formation involves the specification and differentiation of cardiac precursors, the integration of precursors into a tube, and the remodeling of the embryonic tube to create a fully functional organ. Recently, the zebrafish has emerged as a powerful model organism for the analysis of cardiac development. In particular, zebrafish mutations have revealed specific genetic requirements for cardiac fate determination, migration, fusion, tube assembly, looping, and remodeling. These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping