PUBLICATION
Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio
- Authors
- Holtzman, N.G., Iovine, M.K., Liang, J.O., Morris, J.
- ID
- ZDB-PUB-160708-6
- Date
- 2016
- Source
- Genetics 203: 1069-1089 (Review)
- Registered Authors
- Holtzman, Nathalia Glickman, Iovine, M. Kathryn, Liang, Jennifer, Morris, Jacqueline K.
- Keywords
- none
- MeSH Terms
-
- Animals
- Gene Expression Regulation
- Models, Animal*
- Organogenesis/genetics*
- Regeneration/genetics*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/growth & development
- PubMed
- 27384027 Full text @ Genetics
Citation
Holtzman, N.G., Iovine, M.K., Liang, J.O., Morris, J. (2016) Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio. Genetics. 203:1069-1089.
Abstract
In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping