Gene
dnmt1
- ID
- ZDB-GENE-990714-15
- Name
- DNA (cytosine-5-)-methyltransferase 1
- Symbol
- dnmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have DNA (cytosine-5-)-methyltransferase activity and DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin bud. Orthologous to human DNMT1 (DNA methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb983 (12 images)
- cb1075 (16 images)
- IMAGE:7140056 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant cerebellar ataxia, deafness and narcolepsy | Alliance | Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant | 604121 |
| hereditary sensory neuropathy type 1E | Alliance | Neuropathy, hereditary sensory, type IE | 614116 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
| Conserved_site | IPR031303 | DNA methylase, C-5 cytosine-specific, conserved site |
| Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
| Domain | IPR002857 | Zinc finger, CXXC-type |
| Domain | IPR010506 | DMAP1-binding domain |
| Domain | IPR022702 | DNA (cytosine-5)-methyltransferase 1, replication foci domain |
| Family | IPR001525 | C-5 cytosine methyltransferase |
| Family | IPR017198 | DNA (cytosine-5)-methyltransferase 1-like |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR043151 | Bromo adjacent homology (BAH) domain superfamily |
Domain Details Per Protein
| Protein | Length | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | C-5 cytosine methyltransferase | DMAP1-binding domain | DNA (cytosine-5)-methyltransferase 1-like | DNA (cytosine-5)-methyltransferase 1, replication foci domain | DNA methylase, C-5 cytosine-specific, active site | DNA methylase, C-5 cytosine-specific, conserved site | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Zinc finger, CXXC-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YUX4
|
1505 | ||||||||||
|
UniProtKB:F1RCN0
|
1500 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dnmt1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
8 |
Plasmids
No data available