Gene

dnmt1

ID
ZDB-GENE-990714-15
Name
DNA (cytosine-5-)-methyltransferase 1
Symbol
dnmt1 Nomenclature History
Previous Names
  • mta
  • cb1075 (1)
  • cb983 (1)
  • ddn
  • fb05h01
  • wu:fb05h01 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates. Involved in several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and tail bud. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Orthologous to human DNMT1 (DNA methyltransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
34 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant cerebellar ataxia, deafness and narcolepsy Alliance Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 604121
hereditary sensory neuropathy type 1E Alliance Neuropathy, hereditary sensory, type IE 614116
Associated With dnmt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Conserved_site IPR031303 DNA methylase, C-5 cytosine-specific, conserved site
Domain IPR001025 Bromo adjacent homology (BAH) domain
Domain IPR002857 Zinc finger, CXXC-type
Domain IPR010506 DMAP1-binding domain
Domain IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domain
Family IPR001525 C-5 cytosine methyltransferase
Family IPR017198 DNA (cytosine-5)-methyltransferase 1-like
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Homologous_superfamily IPR043151 Bromo adjacent homology (BAH) domain superfamily
Domain Details Per Protein
Protein Length Bromo adjacent homology (BAH) domain Bromo adjacent homology (BAH) domain superfamily C-5 cytosine methyltransferase DMAP1-binding domain DNA (cytosine-5)-methyltransferase 1-like DNA (cytosine-5)-methyltransferase 1, replication foci domain DNA methylase, C-5 cytosine-specific, active site DNA methylase, C-5 cytosine-specific, conserved site S-adenosyl-L-methionine-dependent methyltransferase Zinc finger, CXXC-type
UniProtKB:Q8QGB8 1499
UniProtKB:B3DKL6 1500
UniProtKB:B3DKL7 1500
UniProtKB:Q9YHD9 700
UniProtKB:Q6PFQ6 200
UniProtKB:F1RCN0 1500
UniProtKB:Q803T0 493
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dnmt1 polyclonal IgG Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
7
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations