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ZIRC
ZFIN ID: ZDB-GENE-990714-15
Gene Name: DNA (cytosine-5-)-methyltransferase 1
Gene Symbol: dnmt1    Nomenclature History

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Previous Names: mta, cb1075 (1), cb983 (1), ddn, fb05h01, wu:fb05h01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA (cytosine-5-)-methyltransferase activity and DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin bud. Orthologous to human DNMT1 (DNA methyltransferase 1).
Genome Resources: Alliance (1),  Gene:30430 (1),  Ensembl(GRCz11):ENSDARG00000030756 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pd1093 Point Mutation Unknown Unknown ENU
rj794 Point Mutation Unknown Premature Stop ENU
s872 Point Mutation Unknown Missense ENU
s904 Unknown Unknown Unknown ENU
sa16282 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20150 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40171 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40172 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40173 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40174 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25501 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dnmt1 N/A 3
    MO2-dnmt1 N/A 1
    MO3-dnmt1 N/A 1
    MO4-dnmt1 N/A 11
    MO5-dnmt1 N/A 2
    MO6-dnmt1 N/A 2
    MO7-dnmt1 N/A 2
    MO8-dnmt1 N/A 1
    DISEASE ASSOCIATED WITH dnmt1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant cerebellar ataxia, deafness and narcolepsy Alliance Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 604121
    hereditary sensory neuropathy type 1E Alliance Neuropathy, hereditary sensory, type IE 614116
    DISEASE ASSOCIATED WITH dnmt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 27)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnmt1-201 (1)    Ensembl 4896
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dnmt1 polyclonal IgG Rabbit IHC Santa Cruz Biotechnology, Inc.
    6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnmt1 No data available
    MARKER RELATIONSHIPS
    dnmt1 Contained in: [BAC] CH73-160J1 (1) (order this)
    dnmt1 Encodes: [EST] cb983 (1) (order this), cb1075 (1) (order this), fb05h01 (1), IMAGE:7140056 (1) (order this)
    [cDNA] MGC:66111 (1) (order this), MGC:195320 (1) (order this), MGC:195321 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131189 (1) 4907 bp
    Genomic GenBank:CU571160 (1) 81776 bp
    Select Tool
    Polypeptide UniProtKB:B3DKL6 (1) 1500 aa
    Sequence Clusters UniGene:25162 (1)
    Sequence Information (all 37)
    ORTHOLOGY for dnmt1 ( Chr: 3 )
    CITATIONS (91)