ZFIN ID: ZDB-GENE-990714-15
Gene Name: DNA (cytosine-5-)-methyltransferase 1
Gene Symbol: dnmt1
Sequence Ontology ID : SO:0000704

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Previous Names: mta, cb1075 (1), cb983 (1), ddn, fb05h01, wu:fb05h01 (1)

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA (cytosine-5-)-methyltransferase activity and DNA binding activity; involved in several processes, including Kupffer's vesicle development, animal organ development, and  ...
GENE EXPRESSION
All Expression Data: 29 figures from 12 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb983]
  5 figures (16 images) from Thisse et al., 2001 [cb1075]
  6 figures (5 images) from Thisse et al., 2004 [IMAGE:7140056]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 6 (144.0h-168.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pd1093 Point Mutation Unknown Unknown ENU
rj794 Point Mutation Unknown Premature Stop ENU
s872 Point Mutation Unknown Missense ENU
s904 Unknown Unknown Unknown ENU
sa16282 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20150 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40171 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40172 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40173 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40174 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25501 Point Mutation Unknown Missense ENU
    Targeting reagents:
    PHENOTYPE
    Data: 34 figures from 12 publications
    Observed in:
    DISEASE ASSOCIATED WITH dnmt1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant cerebellar ataxia, deafness and narcolepsy Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 604121
    hereditary sensory neuropathy type 1E Neuropathy, hereditary sensory, type IE 614116
    DISEASE ASSOCIATED WITH dnmt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001025 (1)
  • InterPro:IPR001525 (1)
  • InterPro:IPR002857 (1)
  • InterPro:IPR010506 (1)
  • InterPro:IPR017198 (1)
  • InterPro:IPR018117 (1)
  • InterPro:IPR022702 (1)
  • InterPro:IPR029063 (1)
  • InterPro:IPR031303 (1)
  • PROSITE:PS00094 (1)
  • PROSITE:PS00095 (1)
  • PROSITE:PS51038 (1)
  • PROSITE:PS51058 (1)
  • PROSITE:PS51679 (1)
  • Pfam:PF00145 (1)
  • Pfam:PF01426 (1)
  • Pfam:PF02008 (1)
  • Pfam:PF06464 (1)
  • Pfam:PF12047 (1)
  • EC:2.1.1.37 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA dnmt1-002 (1) 1183
    mRNA dnmt1-201 (1) 4896
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dnmt1 No data available
    MARKER RELATIONSHIPS
    dnmt1Contained in: [BAC] CH73-160J1 (1) (order this)
    dnmt1Encodes: [EST] cb983 (1) (order this), cb1075 (1) (order this), fb05h01 (1), IMAGE:7140056 (1) (order this)
    [cDNA] MGC:66111 (1) (order this), MGC:195320 (1) (order this), MGC:195321 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131189 (1) 4907bp
    Genomic GenBank:CU571160 (1) 81776bp
    Select Tool
    Polypeptide UniProtKB:B3DKL6 (1) 1500aa
    Sequence Clusters UniGene:25162 (1)
    Sequence Information (all 37)
    OTHER dnmt1 GENE PAGES
  • Alliance (1)
  • Gene:30430 (1)
  • VEGA:OTTDARG00000035199 (1)
  • Ensembl(GRCz11):ENSDARG00000030756 (2)
  • ORTHOLOGY for dnmt1 (Chr: 3)
    CITATIONS (84)