Gene
rx1
- ID
- ZDB-GENE-990415-236
- Name
- retinal homeobox gene 1
- Symbol
- rx1 Nomenclature History
- Previous Names
-
- etID309857.22 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within camera-type eye photoreceptor cell differentiation and retina layer formation. Predicted to be located in nucleus. Is expressed in eye; optic cup; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in age related macular degeneration 6; cone-rod dystrophy 11; isolated microphthalmia 3; and retinitis pigmentosa. Orthologous to human RAX (retina and anterior neural fold homeobox) and RAX2 (retina and anterior neural fold homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 48 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Nelson et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rx1 | N/A | Rojas-Munoz et al., 2005 |
| MO2-rx1 | N/A | (2) |
| MO3-rx1 | N/A | Nelson et al., 2009 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, syndromic 16 | 611038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42356 | InterPro | 330 | |||||
| UniProtKB:Q6P984 | InterPro | 330 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(rx1:GAL4-VP16) |
|
| 1 | Ranawat et al., 2021 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63J24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73026 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131225 (1) | 2885 nt | ||
| Genomic | GenBank:CR936300 (1) | 158446 nt | ||
| Polypeptide | UniProtKB:O42356 (1) | 330 aa |
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Kantha, P., Liu, S.T., Horng, J.L., Lin, L.Y. (2022) Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 248:106203
- Huang, L., Liang, H., Wang, S., Chen, S. (2021) m6A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish. Biochemical and Biophysical Research Communications. 567:171-176
- Ranawat, N., Masai, I. (2021) Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLIFE. 10:
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- Choe, S., Huh, T.L., Rhee, M. (2020) Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos. Animal cells and systems. 24:99-106
- Covello, G., Rossello, F.J., Filosi, M., Gajardo, F., Duchemin, A.L., Tremonti, B.F., Eichenlaub, M., Polo, J.M., Powell, D., Ngai, J., Allende, M.L., Domenici, E., Ramialison, M., Poggi, L. (2020) Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases. FASEB bioAdvances. 2:434-448
- Zhao, G., Sun, H., Zhang, T., Liu, J.X. (2020) Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Cell communication and signaling : CCS. 18:45
- Jung, J., Udhaya Kumar, S., Choi, I., Huh, T.L., Rhee, M. (2019) Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos. Animal cells and systems. 23:26-31
1 - 10 of 81
Show