Gene

rx1

ID
ZDB-GENE-990415-236
Name
retinal homeobox gene 1
Symbol
rx1 Nomenclature History
Previous Names
  • etID309857.22 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in camera-type eye photoreceptor cell differentiation and retina layer formation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in eye; optic cup; optic primordium; and optic vesicle. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
47 figures from 37 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Nelson et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 3 Alliance Microphthalmia, isolated 3 611038
Associated With rx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Family IPR043562 Retinal homeobox protein RAX/RAX2
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily OAR domain Retinal homeobox protein RAX/RAX2
UniProtKB:O42356 330
UniProtKB:Q6P984 330
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rx1 polyclonal Guinea pig
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations