ZFIN ID: ZDB-GENE-990415-236
Gene Name: retinal homeobox gene 1
Gene Symbol: rx1    Nomenclature History

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Previous Name: etID309857.22 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in camera-type eye photoreceptor cell differentiation and retina layer formation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in eye; optic cup; optic primordium; and optic vesicle. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources: Alliance (1),  Gene:30472 (1),  Ensembl(GRCz11):ENSDARG00000071684 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-rx1 N/A 1
MO2-rx1 N/A 2
MO3-rx1 N/A 1
DISEASE ASSOCIATED WITH rx1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 3 Alliance Microphthalmia, isolated 3 611038
DISEASE ASSOCIATED WITH rx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye photoreceptor cell differentiation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rx1-201 (1)    Ensembl 2884
ncRNA rx1-002 (1)    Ensembl 938
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-rx1 polyclonal Guinea pig IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rx1 No data available
MARKER RELATIONSHIPS
rx1 Contained in: [BAC] CH211-63J24 (1)
rx1 Encodes: [cDNA] MGC:73026 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131225 (1) 2885 nt
Genomic GenBank:CR936300 (1) 158446 nt
Select Tool
Polypeptide UniProtKB:O42356 (1) 330 aa
Sequence Information (all 11)
ORTHOLOGY for rx1 ( Chr: 22 )
CITATIONS (88)