Gene
mstnb
- ID
- ZDB-GENE-990415-165
- Name
- myostatin b
- Symbol
- mstnb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits growth factor activity. Involved in several processes, including cardiac muscle myoblast proliferation; muscle organ development; and negative regulation of cardiac muscle myoblast proliferation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Is expressed in several structures, including digestive system; heart; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human MSTN (myostatin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myostatin-related muscle hypertrophy | Alliance | ?Muscle hypertrophy | 614160 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|
|
UniProtKB:O42222
|
374 |
Interactions and Pathways
No data available
Plasmids
No data available