Gene

mstnb

ID
ZDB-GENE-990415-165
Name
myostatin b
Symbol
mstnb Nomenclature History
Previous Names
  • mstn-1 (1)
  • mstn
  • gdf8 (1)
  • zgc:109749
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits growth factor activity. Involved in several processes, including muscle organ development; negative regulation of cardiac muscle myoblast proliferation; and negative regulation of growth rate. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; heart; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 15 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mstnb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myostatin-related muscle hypertrophy Alliance Muscle hypertrophy 614160
Associated With mstnb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Family IPR015616 Growth/differentiation factor 8
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Growth/differentiation factor 8 TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:O42222 374
UniProtKB:Q504K3 80
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mstn polyclonal Rabbit
  • WB
Millipore
3
Ab2-mstn polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations