ZFIN ID: ZDB-GENE-990415-165
Gene Name: myostatin b
Gene Symbol: mstnb    Nomenclature History

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Previous Names: mstn-1 (1), mstn, gdf8 (1), zgc:109749

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits growth factor activity. Involved in several processes, including cardiac muscle myoblast proliferation; muscle organ development; and negative regulation of cardiac muscle myoblast proliferation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Is expressed in several structures, including digestive system; heart; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human MSTN (myostatin).
Genome Resources: Alliance (1),  Gene:798441 (1),  Ensembl(GRCz11):ENSDARG00000069133 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns5 Small Deletion Unknown Unknown TALEN
cig3 Small Deletion Unknown Premature Stop CRISPR
ihb167 Indel Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa41499 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf1027 Indel Exon 1 Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mstnb 1
    MO1-mstnb N/A 2
    TALEN1-mstnb 1
    TALEN2-mstnb 1
    DISEASE ASSOCIATED WITH mstnb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    myostatin-related muscle hypertrophy Alliance Muscle hypertrophy 614160
    DISEASE ASSOCIATED WITH mstnb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle organ development (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mstnb-201 (1)    Ensembl 2178
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mstn polyclonal Rabbit WB Millipore
    3
    Ab2-mstn polyclonal Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mstnb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.2mstn:GFP) mstnb GFP Danio rerio 1 3
    Tg(myl7:mstnb-2A-Hsa.HISTH2BJ-EGFP) myl7 2AEGFPmstnb Danio rerioHomo sapiens 1 1
    MARKER RELATIONSHIPS
    mstnb Contained in: [BAC] CH211-3O3 (1)
    [PAC] BUSM1-72B14 (1)
    mstnb Encodes: [EST] eu171 (1)
    [cDNA] MGC:109749 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131019 (1) 2179 nt
    Genomic GenBank:BX323586 (1) 171172 nt
    Select Tool
    Polypeptide UniProtKB:O42222 (1) 374 aa
    Sequence Information (all 27)
    ORTHOLOGY for mstnb ( Chr: 9 )
    CITATIONS (73)