Gene

mstna

ID
ZDB-GENE-050208-735
Name
myostatin a
Symbol
mstna Nomenclature History
Previous Names
  • mstn2 (1)
  • gdf8l
  • myostatin-2 (1)
  • si:dkeyp-84a8.5
  • zfMSTN-2 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have cytokine activity. Involved in immune response. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Is expressed in several structures, including digestive system; eye; heart; muscle; and pleuroperitoneal region. Orthologous to human MSTN (myostatin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Wang et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mstna Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myostatin-related muscle hypertrophy Alliance ?Muscle hypertrophy 614160
Associated With mstna Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Family IPR015616 Growth/differentiation factor 8
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Growth/differentiation factor 8 TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:B3DIZ5 366
UniProtKB:Q68IN2 366
UniProtKB:Q5MNY3 366
UniProtKB:Q4VV68 366
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mstn polyclonal Rabbit
  • WB
Millipore
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations