ZFIN is now using GRCz12tu for Genomic Data
Gene

tbxta

ID
ZDB-GENE-980526-437
Name
T-box transcription factor Ta
Symbol
tbxta Nomenclature History
Previous Names
  • T
  • ta
  • ZF-T (1)
  • zft
  • brachyury
  • cb240 (1)
  • id:ibd5074 (1)
  • no tail a
  • ntl
  • ntla
  • wu:fc80a01 (1)
  • ZF-NTL (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including convergent extension; notochord development; and regionalization. Located in chromatin and nucleus. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
557 figures from 390 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
53 figures from 36 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbxta Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sacral agenesis with vertebral anomalies 615709
{Neural tube defects, susceptibility to} 182940
Associated With tbxta Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR046360 T-box transcription factor, DNA-binding domain
Family IPR001699 T-box transcription factor
Family IPR002070 Transcription factor, Brachyury
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Additional Resources Length p53-like transcription factor, DNA-binding domain superfamily T-box superfamily T-box transcription factor T-box transcription factor, DNA-binding domain Transcription factor, Brachyury Transcription factor, T-box, conserved site
UniProtKB:Q07998 InterPro 423
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tbxta-201 (1)
Ensembl
Ensembl 2,211 nt
ZFIN BLAST
ncRNA ta-002 (1)
Ensembl
Ensembl 851 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ta polyclonal Rabbit
  • IHC
 40
AB3-ta monoclonal IgG1 Mouse
2
Ab2-ta monoclonal Mouse
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.